Chen Zhiliang
Fujian Provincial Key Laboratory of PTH Natural Medicine Research and Development, Zhangzhou PTH Pharmaceutical CO., LTD, Zhangzhou, 363000, China.
Cancer Cell Int. 2021 Mar 3;21(1):146. doi: 10.1186/s12935-021-01785-3.
Pien Tze Huang (PZH) is a well-known Traditional Chinese Medicine (TCM), characterized by a multitude of pharmacological effects, such as hepatoprotection and inhibition of inflammation and cell proliferative conditions. Many of these effects have been validated at the cellular, molecular and physiological levels but, to date, most of these findings have not been comprehensively disclosed.
This review aims to provide a critical summary of recent studies focusing on PZH and its multiple pharmacological effects. As a result, we further discuss some novel perspectives related to PZH's mechanisms of action and a holistic view of its therapeutic activities.
A systematic review was performed focusing on PZH studies originated from original scientific resources. The scientific literature retrieved for this work was obtained from International repositories including NCBI/PubMed, Web of Science, Science Direct and China National Knowledge Infrastructure (CNKI) databases.
The major active componentes and their potential functions, including hepatoprotective and neuroprotective effects, as well as anti-cancer and anti-inflammatory activities, were summarized and categorized accordingly. As indicated, most of the pharmacological effects were validated in vitro and in vivo. The identification of complex bioactive components in PZH may provide the basis for further therapeutic initiatives.
Here we have collectively discussed the recent evidences covering most, if not all, pharmacological effects driven by PZH. This review provides novel perspectives on understanding the modes of action and the holistic view of TCM. The rational development of future clinical trials will certainly provide evidence-based medical evidences that will also confirm the therapeutic advantages of PZH, based on the current information available.
片仔癀是一种著名的传统中药，具有多种药理作用，如保肝、抑制炎症和细胞增殖状况等。其中许多作用已在细胞、分子和生理水平上得到验证，但迄今为止，这些发现大多尚未全面披露。
本综述旨在对近期聚焦片仔癀及其多种药理作用的研究进行批判性总结。在此基础上，我们进一步探讨了与片仔癀作用机制相关的一些新观点及其治疗活性的整体看法。
针对源自原始科学资源的片仔癀研究进行了系统综述。本研究检索的科学文献来自包括NCBI/ PubMed、科学网、Science Direct和中国知网数据库在内的国际数据库。
总结并分类了主要活性成分及其潜在功能，包括保肝和神经保护作用以及抗癌和抗炎活性。如所示，大多数药理作用已在体外和体内得到验证。片仔癀中复杂生物活性成分的鉴定可能为进一步的治疗举措提供依据。
在此，我们共同讨论了涵盖片仔癀驱动的大部分（即便不是全部）药理作用的最新证据。本综述为理解中药的作用模式和整体观点提供了新视角。基于现有信息，未来临床试验的合理开展肯定会提供循证医学证据，也将证实片仔癀的治疗优势。
