Serizawa Kan, Kamei Satoshi, Morita Akihiko, Hara Motohiko, Mizutani Tomohiko, Yoshihashi Hirokazu, Yamaguchi Mai, Takeshita Jun, Hirayanagi Kaname
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
J Clin Neurophysiol. 2008 Dec;25(6):361-6. doi: 10.1097/WNP.0b013e31818f50de.
Quantitative EEG (qEEG) findings in Parkinson disease (PD) have been reported in only five previous studies. In these studies, the sample size was small and the distribution of qEEG changes was not estimated. This is the first qEEG evaluation not only employing multiple logistic regression analysis but also estimating the distribution of qEEG changes. The subjects comprised 45 PD patients without remarkable dementia and 40 age-adjusted normal controls. The lack of ischemic lesions in all subjects was confirmed by MRI. Absolute power values were measured for four frequency bands from delta to beta. The electrodes were divided into six, viz. frontal pole, frontal, central, parietal, temporal, and occipital locations. We calculated the spectral ratio, i.e., the sum of the power values in the alpha and beta waves divided by the sum of the values in the slow waves. The dependent variable was either PD or normal control; the independent variables were the spectral ratios, age, sex, and Mini-Mental State Examination score. The significant predictive variables in PD were the spectral ratios at all electrode locations except for the frontal pole (frontal location: P = 0.025, other locations: P < 0.01). PD presented diffuse slowing in the qEEG when compared with age-adjusted normal controls.
帕金森病（PD）的定量脑电图（qEEG）研究结果此前仅有五项报道。在这些研究中，样本量较小，且未对qEEG变化的分布进行评估。这是首次不仅采用多元逻辑回归分析，还对qEEG变化分布进行评估的qEEG研究。研究对象包括45例无明显痴呆的PD患者和40例年龄匹配的正常对照。通过MRI确认所有受试者均无缺血性病变。测量了从δ波到β波四个频段的绝对功率值。电极分为六个位置，即额极、额叶、中央、顶叶、颞叶和枕叶。我们计算了频谱比，即α波和β波功率值之和除以慢波功率值之和。因变量为PD或正常对照；自变量为频谱比、年龄、性别和简易精神状态检查表评分。PD中显著的预测变量是除额极外所有电极位置的频谱比（额叶位置：P = 0.025，其他位置：P < 0.01）。与年龄匹配的正常对照相比，PD患者的qEEG表现为弥漫性减慢。
