Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
J Clin Neurophysiol. 2009 Dec;26(6):426-9. doi: 10.1097/WNP.0b013e3181c2bce6.
The previous association study confirmed that diffuse slowing of EEGs was present in Parkinson's disease (PD), demonstrated with the use of the quantitative EEG technique. This study was the first to assess the relationship between progression of PD and quantitative EEG. A total of 106 patients with PD with a mean Hoehn-Yahr stage of 2.73 were serially enrolled. Lack of ischemic lesions was confirmed in all patients by magnetic resonance imaging. Absolute power values were measured for four frequency bands from delta to beta. The electrodes were divided among six locations: frontal pole, frontal, central, parietal, temporal, and occipital locations. Spectral ratio was calculated as the sum of power values for the alpha and beta waves divided by the sum values for the slow waves. The relationship between the progression of PD and spectral ratio was assessed by the Jonckheere-Terpstra trend test. At all electrode locations, spectral ratio significantly decreased with progression of Hoehn-Yahr stage (frontal pole, P = 0.007; frontal, P = 0.005; central, P = 0.031; parietal, P = 0.017; temporal, P = 0.005; occipital, P = 0.010). This shows that the slowing of EEGs became more obvious with PD progression.
先前的关联研究证实，帕金森病（PD）患者的脑电图存在弥漫性减慢，这可以通过定量脑电图技术来证明。本研究首次评估了 PD 进展与定量脑电图之间的关系。共连续纳入 106 例平均 Hoehn-Yahr 分期为 2.73 的 PD 患者。所有患者的磁共振成像均证实无缺血性病变。测量了从 delta 波到 beta 波的四个频带的绝对功率值。电极分为六个位置：额极、额部、中央、顶叶、颞叶和枕叶。频谱比计算为 alpha 和 beta 波的功率值之和除以慢波的和值。通过 Jonckheere-Terpstra 趋势检验评估 PD 进展与频谱比之间的关系。在所有电极位置，频谱比随着 Hoehn-Yahr 分期的进展显著降低（额极，P=0.007；额部，P=0.005；中央，P=0.031；顶叶，P=0.017；颞叶，P=0.005；枕叶，P=0.010）。这表明脑电图的减慢随着 PD 的进展变得更加明显。
