1类整合子启动子杂交体2以及强启动子与杂交体1和活性p2启动子组合的相对强度。
Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter.
作者信息
Papagiannitsis Costas C, Tzouvelekis Leonidas S, Miriagou Vivi
机构信息
Laboratory of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
出版信息
Antimicrob Agents Chemother. 2009 Jan;53(1):277-80. doi: 10.1128/AAC.00912-08. Epub 2008 Nov 10.
Abstract
The relative strengths of the uncommon promoters hybrid 2, hybrid 1 with an active P2 promoter (hybrid 1+P2), and strong+P2, which drive transcription of resistance genes in class 1 integrons, were evaluated using bla(GES-1) as a reporter gene cassette. Hybrid 2 was stronger than hybrid 1. Coupling P2 with the strong promoter and with hybrid 1 caused a measurable increase in GES-1 expression.
摘要
使用bla(GES-1)作为报告基因盒，评估了罕见启动子杂交体2、具有活性P2启动子的杂交体1（杂交体1+P2）以及强启动子+P2的相对强度，这些启动子驱动1类整合子中抗性基因的转录。杂交体2比杂交体1更强。将P2与强启动子以及与杂交体1偶联导致GES-1表达有可测量的增加。
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