• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

VIM-12，一种来自肺炎克雷伯菌的新型质粒介导金属β-内酰胺酶，类似于VIM-1/VIM-2杂交体。

VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.

作者信息

Pournaras Spyros, Ikonomidis Alexandros, Tzouvelekis Leonidas S, Tokatlidou Despoina, Spanakis Nicholas, Maniatis Antonios N, Legakis Nicholas J, Tsakris Athanassios

机构信息

Department of Microbiology, Medical School, University of Thessaly, Larissa, Greece.

出版信息

Antimicrob Agents Chemother. 2005 Dec;49(12):5153-6. doi: 10.1128/AAC.49.12.5153-5156.2005.

DOI:10.1128/AAC.49.12.5153-5156.2005
PMID:16304191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1315972/
Abstract

A transferable plasmid from Klebsiella pneumoniae carried a class 1 integron containing bla(VIM-12), a novel bla(VIM)-type gene, flanked by two copies of aacA7. bla(VIM-12) was clustered between bla(VIM-1) and bla(VIM-2) and differed from bla(VIM-1) by 18 nucleotides that were all located at the 3' end and matched the corresponding nucleotides in bla(VIM-2). The bla(VIM-12)-associated 59-base element was identical to that described in bla(VIM-2) alleles.

摘要

一株来自肺炎克雷伯菌的可转移质粒携带一个1类整合子，该整合子含有bla(VIM - 12)，这是一种新型的bla(VIM)型基因，两侧各有一个aacA7拷贝。bla(VIM - 12)聚集在bla(VIM - 1)和bla(VIM - 2)之间，与bla(VIM - 1)有18个核苷酸的差异，这些差异均位于3'端，且与bla(VIM - 2)中的相应核苷酸匹配。与bla(VIM - 12)相关的59碱基元件与bla(VIM - 2)等位基因中描述的元件相同。

相似文献

1
VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.VIM-12，一种来自肺炎克雷伯菌的新型质粒介导金属β-内酰胺酶，类似于VIM-1/VIM-2杂交体。
Antimicrob Agents Chemother. 2005 Dec;49(12):5153-6. doi: 10.1128/AAC.49.12.5153-5156.2005.
2
Characterization of metallo-beta-lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147.A57S 突变体 VIM-1 相关的肺炎克雷伯菌 ST147 金属β-内酰胺酶 VIM-27 的特性。
Antimicrob Agents Chemother. 2011 Jul;55(7):3570-2. doi: 10.1128/AAC.00238-11. Epub 2011 Apr 25.
3
Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.印度肺炎克雷伯菌 14 型携带新型金属β-内酰胺酶基因 bla(NDM-1)和新型红霉素酯酶基因的独特遗传结构特征。
Antimicrob Agents Chemother. 2009 Dec;53(12):5046-54. doi: 10.1128/AAC.00774-09. Epub 2009 Sep 21.
4
Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance.对来自斯堪的纳维亚的产 VIM 肺炎克雷伯菌进行分子特征分析揭示了与编码可转移多药耐药性的国际克隆复合体的遗传相关性。
Clin Microbiol Infect. 2011 Dec;17(12):1811-6. doi: 10.1111/j.1469-0691.2011.03532.x. Epub 2011 May 20.
5
Detection of the new metallo-beta-lactamase VIM-19 along with KPC-2, CMY-2 and CTX-M-15 in Klebsiella pneumoniae.检测肺炎克雷伯菌中的新型金属β-内酰胺酶 VIM-19 以及 KPC-2、CMY-2 和 CTX-M-15。
J Antimicrob Chemother. 2010 Aug;65(8):1604-7. doi: 10.1093/jac/dkq190. Epub 2010 Jun 3.
6
Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia.哥伦比亚肺炎克雷伯菌中分离出的新型 VIM 金属β-内酰胺酶变体 VIM-24。
Antimicrob Agents Chemother. 2011 May;55(5):2428-30. doi: 10.1128/AAC.01208-10. Epub 2011 Jan 31.
7
Ongoing epidemic of blaVIM-1-positive Klebsiella pneumoniae in Athens, Greece: a prospective survey.希腊雅典blaVIM-1阳性肺炎克雷伯菌的持续流行：一项前瞻性调查。
J Antimicrob Chemother. 2008 Jan;61(1):59-63. doi: 10.1093/jac/dkm443. Epub 2007 Nov 13.
8
Escherichia coli with a self-transferable, multiresistant plasmid coding for metallo-beta-lactamase VIM-1.携带编码金属β-内酰胺酶VIM-1的自我转移性多耐药质粒的大肠杆菌。
Antimicrob Agents Chemother. 2003 Jan;47(1):395-7. doi: 10.1128/AAC.47.1.395-397.2003.
9
Complex clonal and plasmid epidemiology in the first outbreak of Enterobacteriaceae infection involving VIM-1 metallo-beta-lactamase in Spain: toward endemicity?西班牙首次爆发涉及VIM-1金属β-内酰胺酶的肠杆菌科感染中的复杂克隆和质粒流行病学：是否会趋于地方流行？
Clin Infect Dis. 2007 Nov 1;45(9):1171-8. doi: 10.1086/522288. Epub 2007 Sep 27.
10
VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae.VIM-19，一种来源于大肠埃希菌和肺炎克雷伯菌的具有增强碳青霉烯酶活性的金属β-内酰胺酶。
Antimicrob Agents Chemother. 2010 Jan;54(1):471-6. doi: 10.1128/AAC.00458-09. Epub 2009 Nov 16.

引用本文的文献

1
Development of constitutive and IPTG-inducible integron promoter-based expression systems for and .用于……和……的基于组成型和IPTG诱导型整合子启动子的表达系统的开发。 （原文中“for and.”部分表述不完整，翻译可能不太准确，需结合完整原文进一步完善）
3 Biotech. 2023 Mar;13(3):91. doi: 10.1007/s13205-023-03507-0. Epub 2023 Feb 20.
2
VIM-encoding Inc plasmids and chromosome-borne integrative and mobilizable elements (IMEs) and integrative and conjugative elements (ICEs) in Pseudomonas.维姆编码 Inc 质粒和染色体携带的整合可移动元件（IMEs）和整合共轭元件（ICEs）在假单胞菌中。
Ann Clin Microbiol Antimicrob. 2022 Mar 9;21(1):10. doi: 10.1186/s12941-022-00502-w.
3
Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.金属β-内酰胺酶在多药耐药时代：从结构和机制到进化、传播和抑制剂设计。
Chem Rev. 2021 Jul 14;121(13):7957-8094. doi: 10.1021/acs.chemrev.1c00138. Epub 2021 Jun 15.
4
Protein determinants of dissemination and host specificity of metallo-β-lactamases.金属β-内酰胺酶传播和宿主特异性的蛋白决定因素。
Nat Commun. 2019 Aug 9;10(1):3617. doi: 10.1038/s41467-019-11615-w.
5
Ceftazidime Is the Key Diversification and Selection Driver of VIM-Type Carbapenemases.头孢他啶是 VIM 型碳青霉烯酶的关键多样化和选择驱动因素。
mBio. 2018 May 8;9(3):e02109-17. doi: 10.1128/mBio.02109-17.
6
Colonization, Infection, and the Accessory Genome of .定植、感染与. 的附属基因组
Front Cell Infect Microbiol. 2018 Jan 22;8:4. doi: 10.3389/fcimb.2018.00004. eCollection 2018.
7
Draft Genome Sequence of Escherichia coli 26R 793, a Plasmid-Free Recipient Strain Commonly Used in Conjugation Assays.大肠杆菌26R 793的基因组序列草图，一种常用于接合试验的无质粒受体菌株。
Genome Announc. 2016 Oct 20;4(5):e00707-16. doi: 10.1128/genomeA.00707-16.
8
Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-β-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece.VIM-39的生化特性研究，VIM-39是一种来自希腊的耐多药肺炎克雷伯菌分离株的类VIM-1金属β-内酰胺酶变体
Antimicrob Agents Chemother. 2015 Dec;59(12):7811-4. doi: 10.1128/AAC.01935-15. Epub 2015 Sep 14.
9
Systematic analysis of metallo-β-lactamases using an automated database.利用自动化数据库对金属β-内酰胺酶进行系统分析。
Antimicrob Agents Chemother. 2012 Jul;56(7):3481-91. doi: 10.1128/AAC.00255-12. Epub 2012 Apr 30.
10
Emergence of VIM-12 in Enterobacter cloacae.肠杆菌科出现 VIM-12。
J Clin Microbiol. 2010 Sep;48(9):3414-5. doi: 10.1128/JCM.00843-10. Epub 2010 Jun 30.

本文引用的文献

1
Metallo-beta-lactamases: the quiet before the storm?金属β-内酰胺酶：暴风雨前的宁静？
Clin Microbiol Rev. 2005 Apr;18(2):306-25. doi: 10.1128/CMR.18.2.306-325.2005.
2
CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid.CMY-13，一种由大肠杆菌质粒编码的新型诱导型头孢菌素酶。
Antimicrob Agents Chemother. 2004 Aug;48(8):3172-4. doi: 10.1128/AAC.48.8.3172-3174.2004.
3
VIM-1 Metallo-beta-lactamase-producing Klebsiella pneumoniae strains in Greek hospitals.希腊医院中产生VIM-1金属β-内酰胺酶的肺炎克雷伯菌菌株。
J Clin Microbiol. 2003 Aug;41(8):3893-6. doi: 10.1128/JCM.41.8.3893-3896.2003.
4
Hospital outbreak of multiple clones of Pseudomonas aeruginosa carrying the unrelated metallo-beta-lactamase gene variants blaVIM-2 and blaVIM-4.医院爆发携带不相关金属β-内酰胺酶基因变体blaVIM-2和blaVIM-4的多重铜绿假单胞菌克隆。
J Antimicrob Chemother. 2003 Jun;51(6):1409-14. doi: 10.1093/jac/dkg239. Epub 2003 Apr 25.
5
On functional and structural heterogeneity of VIM-type metallo-beta-lactamases.关于VIM型金属β-内酰胺酶的功能和结构异质性
J Antimicrob Chemother. 2003 Feb;51(2):257-66. doi: 10.1093/jac/dkg067.
6
Escherichia coli with a self-transferable, multiresistant plasmid coding for metallo-beta-lactamase VIM-1.携带编码金属β-内酰胺酶VIM-1的自我转移性多耐药质粒的大肠杆菌。
Antimicrob Agents Chemother. 2003 Jan;47(1):395-7. doi: 10.1128/AAC.47.1.395-397.2003.
7
Emerging carbapenemases in Gram-negative aerobes.革兰氏阴性需氧菌中新型碳青霉烯酶的出现。
Clin Microbiol Infect. 2002 Jun;8(6):321-31. doi: 10.1046/j.1469-0691.2002.00401.x.
8
Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.台湾临床分离的假单胞菌中的金属β-内酰胺酶以及VIM-2酶新变体VIM-3的鉴定
Antimicrob Agents Chemother. 2001 Aug;45(8):2224-8. doi: 10.1128/AAC.45.8.2224-2228.2001.
9
In70 of plasmid pAX22, a bla(VIM-1)-containing integron carrying a new aminoglycoside phosphotransferase gene cassette.在质粒pAX22的70中，一个携带新氨基糖苷磷酸转移酶基因盒的含bla(VIM-1)整合子。 （注：这段英文表述不太准确规范，翻译出来的中文也稍显生硬，但完全按照要求进行了翻译）
Antimicrob Agents Chemother. 2001 Apr;45(4):1249-53. doi: 10.1128/AAC.45.4.1249-1253.2001.
10
Standard numbering scheme for class B beta-lactamases.B类β-内酰胺酶的标准编号方案。
Antimicrob Agents Chemother. 2001 Mar;45(3):660-3. doi: 10.1128/AAC.45.3.660-663.2001.