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本文引用的文献

1
Contribution of extended-spectrum AmpC (ESAC) beta-lactamases to carbapenem resistance in Escherichia coli.超广谱AmpC（ESAC）β-内酰胺酶对大肠杆菌碳青霉烯耐药性的作用。
FEMS Microbiol Lett. 2008 May;282(2):238-40. doi: 10.1111/j.1574-6968.2008.01126.x. Epub 2008 Mar 27.
2
Molecular characterization of AmpC-producing Escherichia coli clinical isolates recovered in a French hospital.在一家法国医院分离出的产AmpC型大肠杆菌临床菌株的分子特征分析
J Antimicrob Chemother. 2008 Mar;61(3):498-503. doi: 10.1093/jac/dkm538. Epub 2008 Feb 4.
3
Extended-spectrum cephalosporinases: structure, detection and epidemiology.超广谱头孢菌素酶：结构、检测与流行病学
Future Microbiol. 2007 Jun;2(3):297-307. doi: 10.2217/17460913.2.3.297.
4
Extension of the hydrolysis spectrum of AmpC beta-lactamase of Escherichia coli due to amino acid insertion in the H-10 helix.由于H-10螺旋中氨基酸插入导致大肠杆菌AmpCβ-内酰胺酶水解谱的扩展。
J Antimicrob Chemother. 2007 Sep;60(3):490-4. doi: 10.1093/jac/dkm227. Epub 2007 Jun 22.
5
Naturally occurring extended-spectrum cephalosporinases in Escherichia coli.大肠杆菌中天然存在的超广谱头孢菌素酶
Antimicrob Agents Chemother. 2006 Jul;50(7):2573-6. doi: 10.1128/AAC.01633-05.
6
Structural basis for the extended substrate spectrum of CMY-10, a plasmid-encoded class C beta-lactamase.质粒编码的C类β-内酰胺酶CMY-10扩展底物谱的结构基础
Mol Microbiol. 2006 May;60(4):907-16. doi: 10.1111/j.1365-2958.2006.05146.x.
7
Resistance to cefepime and cefpirome due to a 4-amino-acid deletion in the chromosome-encoded AmpC beta-lactamase of a Serratia marcescens clinical isolate.一株粘质沙雷氏菌临床分离株的染色体编码AmpCβ-内酰胺酶中4个氨基酸缺失导致对头孢吡肟和头孢匹罗耐药。
Antimicrob Agents Chemother. 2004 Mar;48(3):716-20. doi: 10.1128/AAC.48.3.716-720.2004.
8
Structure-based approach for binding site identification on AmpC beta-lactamase.基于结构的AmpCβ-内酰胺酶结合位点识别方法。
J Med Chem. 2002 Jul 18;45(15):3222-34. doi: 10.1021/jm020002p.
9
Rapid and simple determination of the Escherichia coli phylogenetic group.快速简便地测定大肠杆菌的系统发育群。
Appl Environ Microbiol. 2000 Oct;66(10):4555-8. doi: 10.1128/AEM.66.10.4555-4558.2000.
10
Analysis of the effects of -42 and -32 ampC promoter mutations in clinical isolates of Escherichia coli hyperproducing ampC.大肠埃希菌高产AmpC临床分离株中-42和-32 AmpC启动子突变的影响分析
J Antimicrob Chemother. 2000 Jun;45(6):783-8. doi: 10.1093/jac/45.6.783.

丝氨酸287位替换为天冬酰胺在大肠杆菌AmpCβ-内酰胺酶水解谱扩展中的作用

Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli.

作者信息

Mammeri Hedi, Galleni Moreno, Nordmann Patrice

机构信息

Service de Bactériologie-Hygiène, Centre Hospitalier Universitaire d'Amiens, Hôpital Nord, Amiens, France.

出版信息

Antimicrob Agents Chemother. 2009 Jan;53(1):323-6. doi: 10.1128/AAC.00608-08. Epub 2008 Nov 10.

DOI:10.1128/AAC.00608-08
PMID:19001118
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2612185/
Abstract

Two AmpC variants harboring the S287N substitution were obtained by mutagenesis from cephalosporinases representative of the phylogenetic groups A and B2 of Escherichia coli. Their biochemical characterization revealed that the S287N replacement led to an important increase in the catalytic efficiency toward extended-spectrum cephalosporins in the AmpC beta-lactamase of group A only.

摘要

通过诱变从大肠杆菌系统发育群A和B2的头孢菌素酶中获得了两个携带S287N取代的AmpC变体。它们的生化特性表明，只有在A组的AmpCβ-内酰胺酶中，S287N取代导致对超广谱头孢菌素的催化效率显著提高。