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本文引用的文献

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Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases.五种质粒介导的 AmpC β-内酰胺酶碳青霉烯水解活性的表型和生化比较。
Antimicrob Agents Chemother. 2010 Nov;54(11):4556-60. doi: 10.1128/AAC.01762-09. Epub 2010 Aug 23.
2
Extended-spectrum-beta-lactamase, AmpC, and Carbapenemase issues.超广谱β-内酰胺酶、AmpC酶和碳青霉烯酶问题。
J Clin Microbiol. 2010 Apr;48(4):1019-25. doi: 10.1128/JCM.00219-10. Epub 2010 Feb 24.
3
Occurrence of ST23 complex phylogroup A Escherichia coli isolates producing extended-spectrum AmpC beta-lactamase in a French hospital.法国某医院产超广谱 AmpCβ-内酰胺酶的 ST23 复合群 A 型大肠埃希菌的发生。
Antimicrob Agents Chemother. 2010 May;54(5):2216-8. doi: 10.1128/AAC.01580-09. Epub 2010 Feb 9.
4
Updated functional classification of beta-lactamases.β-内酰胺酶的功能分类更新。
Antimicrob Agents Chemother. 2010 Mar;54(3):969-76. doi: 10.1128/AAC.01009-09. Epub 2009 Dec 7.
5
Molecular characterization of AmpC-producing Escherichia coli clinical isolates recovered at two Belgian hospitals.在比利时两家医院分离出的产AmpC大肠杆菌临床分离株的分子特征分析
Pathol Biol (Paris). 2010 Feb;58(1):78-83. doi: 10.1016/j.patbio.2009.07.035. Epub 2009 Nov 4.
6
Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK.破坏英国产耐厄他培南克雷伯菌和肠杆菌临床分离株中孔蛋白表达的分子机制。
J Antimicrob Chemother. 2009 Apr;63(4):659-67. doi: 10.1093/jac/dkp029. Epub 2009 Feb 20.
7
CTX-M expression and selection of ertapenem resistance in Klebsiella pneumoniae and Escherichia coli.肺炎克雷伯菌和大肠杆菌中CTX-M的表达与厄他培南耐药性的选择
Antimicrob Agents Chemother. 2009 Feb;53(2):832-4. doi: 10.1128/AAC.01007-08. Epub 2008 Nov 24.
8
Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli.丝氨酸287位替换为天冬酰胺在大肠杆菌AmpCβ-内酰胺酶水解谱扩展中的作用
Antimicrob Agents Chemother. 2009 Jan;53(1):323-6. doi: 10.1128/AAC.00608-08. Epub 2008 Nov 10.
9
Contribution of extended-spectrum AmpC (ESAC) beta-lactamases to carbapenem resistance in Escherichia coli.超广谱AmpC（ESAC）β-内酰胺酶对大肠杆菌碳青霉烯耐药性的作用。
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10
Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss.来自土耳其的产OXA-48样碳青霉烯酶且外膜蛋白缺失的耐碳青霉烯类大肠杆菌和肺炎克雷伯菌分离株
Int J Antimicrob Agents. 2008 Jun;31(6):523-6. doi: 10.1016/j.ijantimicag.2008.01.017. Epub 2008 Mar 12.

产超广谱β-内酰胺酶 AmpC 的大肠埃希菌临床分离株中厄他培南耐药性的出现。

Emergence of ertapenem resistance in an Escherichia coli clinical isolate producing extended-spectrum beta-lactamase AmpC.

机构信息

Service de Bactériologie, Centre Hospitalo-Universitaire d'Amiens, Hôpital Nord, Place Victor Pauchet, 80054 Amiens, France.

出版信息

Antimicrob Agents Chemother. 2011 Sep;55(9):4443-6. doi: 10.1128/AAC.01513-10. Epub 2011 Jul 11.

DOI:10.1128/AAC.01513-10
PMID:21746958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3165280/
Abstract

Escherichia coli isolate MEV, responsible for a bloodstream infection, was resistant to penicillins, cephalosporins, and ertapenem. Molecular and biochemical characterization revealed the production of a novel, chromosome-borne, extended-spectrum AmpC (ESAC) β-lactamase with a Ser-282 duplication and increased carbapenemase activity. This study demonstrates for the first time that chromosome-borne ESAC β-lactamases can contribute to the emergence of ertapenem resistance in E. coli clinical isolates.

摘要

一株导致血流感染的大肠杆菌分离株 MEV 对青霉素类、头孢菌素类和厄他培南耐药。分子和生化特征表明，它产生了一种新型、染色体携带的、超广谱 AmpC（ESAC）β-内酰胺酶，具有丝氨酸-282 重复和增加的碳青霉烯酶活性。本研究首次证明，染色体携带的 ESAC β-内酰胺酶可导致大肠杆菌临床分离株厄他培南耐药性的出现。