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Are Parkinson disease patients protected from some but not all cancers?

作者信息

Strongosky Audrey J, Farrer Matthew, Wszolek Zbigniew K

出版信息

Neurology. 2008 Nov 11;71(20):1650; author reply 1650-1. doi: 10.1212/01.wnl.0000339367.54460.8c.

DOI:10.1212/01.wnl.0000339367.54460.8c
PMID:19001259
Abstract
摘要

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LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair.LRRK2抑制通过抑制同源重组介导的DNA双链断裂修复增强PARP抑制剂的细胞毒性。
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Cancer in Parkinson's disease.
帕金森病中的癌症
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