Department of Neurology, The Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel.
J Neural Transm (Vienna). 2009 Nov;116(11):1503-7. doi: 10.1007/s00702-009-0322-x.
Although the risk for most cancers appears to be relatively low in patients with Parkinson's disease (PD), skin cancers and melanomas occur more frequently in the PD population as compared to controls. This article summarizes the findings of cohort studies on skin cancer in Parkinson's disease. Given that melanoma may precede use of L-dopa, the increased risk of melanoma for PD patients cannot be attributed to L-dopa. On the basis of these observations it may be reasonable to recommend that all patients with PD, whether treated with L-dopa or not, should undergo regular dermatological screening for neoplastic or pre-neoplastic skin lesions, especially melanoma.
虽然帕金森病（PD）患者发生大多数癌症的风险似乎相对较低，但与对照组相比，PD 人群中皮肤癌和黑色素瘤的发生率更高。本文总结了关于帕金森病皮肤癌的队列研究结果。鉴于黑色素瘤可能先于左旋多巴的使用，因此 PD 患者黑色素瘤风险的增加不能归因于左旋多巴。基于这些观察结果，建议所有 PD 患者（无论是否接受左旋多巴治疗）都应定期进行皮肤癌筛查，以发现肿瘤或癌前皮肤病变，尤其是黑色素瘤，这可能是合理的。
