多发性硬化症患者两年内的吸烟状况。
Smoking status over two years in patients with multiple sclerosis.
机构信息
Department of Medicine, University of Manitoba, Winnipeg, Man., Canada.
出版信息
Neuroepidemiology. 2009;32(1):72-9. doi: 10.1159/000170910. Epub 2008 Nov 12.
BACKGROUND
Smoking increases the risk of multiple sclerosis (MS) and possibly disease progression. The reliability of self-reported smoking status is unknown in MS. We assessed the reliability of self-reported smoking status among participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry.
METHODS
In 2004 and 2006, NARCOMS participants reported smoking status using Behavioral Risk Factor Surveillance Survey questions. We compared responses from 5,458 participants answering both questionnaires. We measured agreement regarding smoking status (ever/current) using a kappa coefficient, and agreement for ages of starting and quitting smoking, and number of cigarettes smoked using an intraclass correlation coefficient (ICC).
RESULTS
In 2004, 2,885 (53.4%) participants reported ever smoking. The kappa coefficient for ever smoking was 0.90 (95% confidence interval, CI: 0.89-0.92) and for current smoking 0.92 (95% CI: 0.90-0.94). The ICC for age at starting smoking was 0.73 (95% CI: 0.71-0.75) and for age at quitting smoking 0.90 (95% CI: 0.89-0.91). African-Americans, younger participants and those of lower socioeconomic status were less reliable. Depressed participants reported current smoking status less consistently (odds ratio: 0.51; 95% CI: 0.39-0.67).
CONCLUSIONS
NARCOMS participants reliably report smoking status. The impact of depression on reliability of self-reported smoking status needs re-evaluation.
背景
吸烟会增加多发性硬化症（MS）的风险，并且可能会加速疾病的进展。MS 患者自我报告吸烟状况的可靠性尚不清楚。我们评估了北美多发性硬化症研究委员会（NARCOMS）注册中心参与者自我报告吸烟状况的可靠性。
方法
2004 年和 2006 年，NARCOMS 参与者使用行为风险因素监测调查问题报告吸烟状况。我们比较了回答两份问卷的 5458 名参与者的回答。我们使用 Kappa 系数比较吸烟状况（曾经/现在）的一致性，使用组内相关系数（ICC）比较开始吸烟和戒烟年龄以及吸烟数量的一致性。
结果
2004 年，2885 名（53.4%）参与者报告曾经吸烟。曾经吸烟的 Kappa 系数为 0.90（95%置信区间，CI：0.89-0.92），现在吸烟的 Kappa 系数为 0.92（95% CI：0.90-0.94）。开始吸烟年龄的 ICC 为 0.73（95% CI：0.71-0.75），戒烟年龄的 ICC 为 0.90（95% CI：0.89-0.91）。非裔美国人、年轻参与者和社会经济地位较低的参与者报告的吸烟状况一致性较差。抑郁的参与者报告现在吸烟状况不一致（比值比：0.51；95% CI：0.39-0.67）。
结论
NARCOMS 参与者可靠地报告吸烟状况。抑郁对自我报告吸烟状况可靠性的影响需要重新评估。
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