Department of Internal Medicine, University of Manitoba, Winnipeg, Man., Canada. rmarrie @ hsc.mb.ca
Neuroepidemiology. 2011;36(2):85-90. doi: 10.1159/000323948. Epub 2011 Feb 1.
BACKGROUND/AIMS: Smoking is a risk factor for multiple sclerosis (MS) and autoimmune disease, and might explain an increased risk of comorbid autoimmune disease (CAD) in MS. We compared the risk of CAD in smokers and nonsmokers with MS.
Participants enrolled in the North American Research Committee on Multiple Sclerosis Registry reported their smoking status, the presence of CAD and the year of diagnosis. We used multivariable logistic regression to determine the independent association between smoking and CAD. We also compared the risk of developing a CAD in current smokers versus never-smokers who did not report any CAD at MS onset, using a proportional hazards model.
Among 8,875 participants reporting comorbidities and smoking status, 1,649 (18.5%) reported a CAD. In a multivariable logistic model, ever-smokers had increased odds of reporting a CAD (odds ratio: 1.22; 95% CI: 1.08-1.38). Among the 7,830 participants without a CAD at onset of MS who reported their smoking status, including the age at which they started smoking, 3,035 (36.8%) currently smoked, while 3,805 (48.6%) never smoked. After adjustment, smokers had an increased risk of developing any autoimmune disease (hazard ratio: 1.23; 95% CI: 1.08-1.41) after MS onset.
Smoking is associated with an increased risk of CAD in MS.
背景/目的：吸烟是多发性硬化症（MS）和自身免疫性疾病的危险因素，可能解释了 MS 患者合并自身免疫性疾病（CAD）的风险增加。我们比较了吸烟的 MS 患者和不吸烟的 MS 患者发生 CAD 的风险。
参与北美多发性硬化症研究委员会注册的参与者报告了他们的吸烟状况、CAD 的存在和诊断年份。我们使用多变量逻辑回归来确定吸烟与 CAD 之间的独立关联。我们还使用比例风险模型比较了当前吸烟者与从未吸烟且在 MS 发病时未报告任何 CAD 的非吸烟者发生 CAD 的风险。
在报告合并症和吸烟状况的 8875 名参与者中，1649 名（18.5%）报告了 CAD。在多变量逻辑模型中，曾经吸烟者报告 CAD 的几率增加（比值比：1.22；95%置信区间：1.08-1.38）。在 7830 名在 MS 发病时未报告 CAD 但报告了吸烟状况的参与者中，包括开始吸烟的年龄，3035 名（36.8%）目前吸烟，而 3805 名（48.6%）从不吸烟。调整后，吸烟者在 MS 发病后发生任何自身免疫性疾病的风险增加（风险比：1.23；95%置信区间：1.08-1.41）。
吸烟与 MS 患者 CAD 风险增加相关。
