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暴露于混合颗粒物和臭氧环境中受到控制时，心率变异性会降低。

Controlled exposure to combined particles and ozone decreases heart rate variability.

作者信息

Power Karron LeGarie, Balmes John, Solomon Colin

机构信息

Lung Biology Center, University of California, Northern California Center for Occupational and Environmental Health, San Francisco, Calif, USA.

出版信息

J Occup Environ Med. 2008 Nov;50(11):1253-60. doi: 10.1097/JOM.0b013e3181814239.

DOI:10.1097/JOM.0b013e3181814239

PMID:19001951

Abstract

OBJECTIVE

This experiment was designed to test if controlled exposure to particles and ozone would result in decreased heart rate variability (HRV).

METHODS

Five asthmatic adults were exposed for 4 hours to; filtered-air, carbon and ammonium nitrate particles, and particles and ozone. Twenty-minute electrocardiograms were obtained before and after each exposure.

RESULTS

Standard deviation of all normal-to-normal beat intervals (SDNN) decreased significantly across particles and ozone exposure compared with across filtered-air exposure (P = 0.01). Changes in SDNN-I (P = 0.04) and normalized low and high frequency (P = 0.02) were also seen across particles and ozone exposure; although these changes may best be characterized as trends given the small sample size. No significant changes in HRV were seen across the filtered-air or particles-only exposures.

CONCLUSIONS

The results of this study suggest that combined particle and ozone exposure may decrease HRV in asthmatics. Further investigation is needed to confirm this finding.

摘要

目的

本实验旨在测试对颗粒物和臭氧的受控暴露是否会导致心率变异性（HRV）降低。

方法

五名成年哮喘患者分别暴露于过滤空气、碳和硝酸铵颗粒以及颗粒与臭氧环境中4小时。每次暴露前后均记录20分钟的心电图。

结果

与暴露于过滤空气相比，暴露于颗粒和臭氧环境后，所有正常心动周期间期的标准差（SDNN）显著降低（P = 0.01）。在颗粒和臭氧暴露过程中，SDNN-I（P = 0.04）以及归一化低频和高频（P = 0.02）也出现了变化；不过鉴于样本量较小，这些变化最好被描述为趋势。在过滤空气或仅颗粒暴露过程中，HRV未出现显著变化。