转化生长因子-β/骨形态发生蛋白（TGF-β/BMP）与其他信号通路之间的信号串扰。
Signaling cross-talk between TGF-beta/BMP and other pathways.
作者信息
Guo Xing, Wang Xiao-Fan
机构信息
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Cell Res. 2009 Jan;19(1):71-88. doi: 10.1038/cr.2008.302.
Abstract
Transforming growth factor-beta (TGF-beta)/bone morphogenic protein (BMP) signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of all metazoans. Deregulation of TGF-beta/BMP activity almost invariably leads to developmental defects and/or diseases, including cancer. The proper functioning of the TGF-beta/BMP pathway depends on its constitutive and extensive communication with other signaling pathways, leading to synergistic or antagonistic effects and eventually desirable biological outcomes. The nature of such signaling cross-talk is overwhelmingly complex and highly context-dependent. Here we review the different modes of cross-talk between TGF-beta/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/Akt, Wnt, Hedgehog, Notch, and the interleukin/interferon-gamma/tumor necrosis factor-alpha cytokines, with an emphasis on the underlying molecular mechanisms.
摘要
转化生长因子-β（TGF-β）/骨形态发生蛋白（BMP）信号传导参与绝大多数细胞过程，并且在所有后生动物的整个生命过程中都至关重要。TGF-β/BMP活性失调几乎总是导致发育缺陷和/或疾病，包括癌症。TGF-β/BMP信号通路的正常运作取决于其与其他信号通路的组成性和广泛通讯，从而产生协同或拮抗作用，并最终导致理想的生物学结果。这种信号串扰的本质极其复杂且高度依赖于上下文。在此，我们综述了TGF-β/BMP与丝裂原活化蛋白激酶、磷脂酰肌醇-3激酶/Akt、Wnt、Hedgehog、Notch以及白细胞介素/干扰素-γ/肿瘤坏死因子-α细胞因子的信号通路之间串扰的不同模式，重点关注其潜在的分子机制。
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