Corazza Monica, Lauriola Maria Michela, Borghi Alessandro, Marzola Andrea, Virgili Annarosa
Department of Clinical and Experimental Medicine, Section of Dermatology, University of Ferrara, Ferrara, Italy.
Acta Derm Venereol. 2008;88(6):601-6. doi: 10.2340/00015555-0526.
The aim of this paper is to report our clinical experience of Sweet's syndrome, a severe dermatological disease which may be extremely important to recognize for the early diagnosis of a neoplastic disorder. Eleven patients affected by Sweet's syndrome, treated at the Department of Dermatology, University of Ferrara, Ferrara, Italy, during 1998 to 2004, were evaluated. A retrospective analysis was performed. Data on age, sex distribution, clinical data, histopathological and immunohistochemical findings and therapy were collected. We observed one patient with idiopathic form, 5 patients affected by the para-inflammatory variant and 5 para-neoplastic cases (with haemoproliferative diseases). The cases with the para-inflammatory form were affected by minor infectious manifestations. Prolonged follow-up is necessary to verify that a case of idiopathic variant is not really a paraneoplastic form. Based on immunohistochemical analysis, we cannot exclude that true histiocytes, immunoreactive for CD68/PGM, infiltrate the dermis in Sweet's syndrome lesions.
本文旨在报告我们关于Sweet综合征的临床经验。Sweet综合征是一种严重的皮肤病，对于肿瘤性疾病的早期诊断而言，认识它可能极其重要。我们评估了1998年至2004年期间在意大利费拉拉大学皮肤科接受治疗的11例Sweet综合征患者。进行了回顾性分析。收集了有关年龄、性别分布、临床数据、组织病理学和免疫组化结果以及治疗方面的数据。我们观察到1例特发性形式的患者、5例受副炎症性变体影响的患者以及5例副肿瘤性病例（伴有血液增殖性疾病）。副炎症性形式的病例伴有轻微感染表现。需要进行长期随访以证实特发性变体病例并非真正的副肿瘤性形式。基于免疫组化分析，我们不能排除真正的组织细胞（对CD68/PGM呈免疫反应性）浸润Sweet综合征皮损真皮层的可能性。
