氯仿萃取的伊朗葱，葱属 hirtifolium，对肿瘤细胞系的抗增殖活性。
Antiproliferative activity of chloroformic extract of Persian Shallot, Allium hirtifolium, on tumor cell lines.
机构信息
Institute of Biochemistry and Biophysics (IBB), University of Tehran, P.O. Box 13145-1384, Tehran, Iran,
出版信息
Cytotechnology. 2008 Mar;56(3):179-85. doi: 10.1007/s10616-008-9145-0. Epub 2008 Apr 11.
Abstract
Allium hirtifolim (Persian Shallot) belongs to Allium genus (Alliaceae family). We investigated the in vitro effects of chloroformic extract of A. hirtifolium and its Allicin on the proliferation of HeLa (cervical cancer), MCF7 (human, caucasion, breast, adenocarcinoma) and L929 (mouse, C3H/An, connective) cell lines. Our results showed that components of A. hirtifolium might inhibit proliferation of tumor cell lines. This inhibition in HeLa and MCF-7 cells was dose-dependent. The presence of Allicin was evaluated by TLC method in bulbs and the extract of A. hirtifolium was analyzed by HPLC. MTT test was performed 24, 48 and 72 h after cell culture. A significant decrease in cell lines was observed in HeLa and MCF-7 as compared to L929 cell lines. DNA fragmentation analysis revealed a large number of apoptotic cells in treated HeLa and MCF-7 cell groups, but no effects in L929 cells. Therefore A. hirtifolium might be a candidate for tumor suppression.
摘要
葱属植物（葱属植物）属于葱属（葱科）。我们研究了 A. hirtifolium 的氯仿提取物及其大蒜素对 HeLa（宫颈癌）、MCF7（人，白种人，乳腺，腺癌）和 L929（鼠，C3H/An，结缔组织）细胞系增殖的体外影响。我们的结果表明，A. hirtifolium 的成分可能抑制肿瘤细胞系的增殖。这种抑制作用在 HeLa 和 MCF-7 细胞中呈剂量依赖性。TLC 法评价鳞茎中大蒜素的存在，HPLC 法分析 A. hirtifolium 的提取物。细胞培养 24、48 和 72 小时后进行 MTT 试验。与 L929 细胞系相比，HeLa 和 MCF-7 细胞系的细胞数量明显减少。DNA 片段分析显示，在处理的 HeLa 和 MCF-7 细胞组中出现大量凋亡细胞，但在 L929 细胞中没有影响。因此，A. hirtifolium 可能是肿瘤抑制的候选药物。
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