体内神经保护肽 AB 对缺血损伤的作用
In vivo Neuroprotective Activity of Epopeptide AB Against Ischemic Damage.
机构信息
Laboratory of Biosignals and Response, Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, 606-8502, Kyoto, Japan,
出版信息
Cytotechnology. 2005 Jan;47(1-3):139-44. doi: 10.1007/s10616-005-3758-3.
Erythropoietin (Epo) is a hematopoietic factor, which stimulates proliferation and differentiation of erythroid precursor cells. Epo also functions as a neuroprotective factor and protects neurons from ischemic damage. Recently a 17-mer peptide sequence (Epopeptide AB) in Epo (AEHCSLNENITVPDTKV) with a neuroprotective function was reported. In this study, we showed in vivo evidence that Epopeptide AB protected neurons from ischemic damage at similar dose compared to Epo. Epopeptide AB could not stimulate the proliferation of Epo-dependent growing murine myeloid Ep-FDC-P2 cells and also did not compete the proliferative function of Epo on these cells. Together with these results, Epopeptide AB did not transduce signals through direct binding to the known Epo receptor on hematopoietic cells but has neuroprotective activity against ischemia.
促红细胞生成素（Epo）是一种造血因子，可刺激红系前体细胞的增殖和分化。Epo 还具有神经保护作用，可防止神经元免受缺血性损伤。最近，报道了 Epo 中具有神经保护功能的 17 肽序列（Epopeptide AB）（AEHCSLNENITVPDTKV）。在这项研究中，我们体内实验的证据表明，与 Epo 相比，Epopeptide AB 以相似的剂量保护神经元免受缺血性损伤。Epopeptide AB 不能刺激依赖 Epo 的生长的鼠髓系 Ep-FDC-P2 细胞的增殖，也不能竞争 Epo 对这些细胞的增殖功能。这些结果表明，Epopeptide AB 并未通过直接与造血细胞上已知的 Epo 受体结合来传递信号，而是具有针对缺血的神经保护活性。
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