妊娠合并糖尿病或先兆子痫时的晚期糖基化终末产物
Advanced glycation end products in pregnancies complicated with diabetes mellitus or preeclampsia.
作者信息
Harsem Nina K, Braekke Kristin, Torjussen Tale, Hanssen Kristian, Staff Anne Cathrine
机构信息
Department of Obstetrics and Gynecology, Ulleval University Hospital, Oslo, Norway.
出版信息
Hypertens Pregnancy. 2008;27(4):374-86. doi: 10.1080/10641950802000968.
OBJECTIVE
Preeclampsia (PE) and diabetes mellitus (DM) are associated with oxidative stress. DM is complicated with formation of advanced glycation end products (AGEs), which are associated with oxidative stress. We hypothesized that elevated serum AGE would be found in pregnancies complicated by PE or DM.
METHODS
Circulating AGEs, 8-isoprostane, vitamin E, and antioxidant capacity were analyzed from study patients.
RESULTS
Serum AGE was elevated both in patients with type 1 DM and gestational DM, but not in PE, compared with controls. 8-isoprostane was elevated in patients with type 1 DM and PE compared with controls.
CONCLUSION
AGEs and 8-isoprostane are not elevated in parallel in pregnancies complicated with PE or DM, suggesting biological heterogeneity.
目的
子痫前期（PE）和糖尿病（DM）与氧化应激相关。糖尿病并发晚期糖基化终末产物（AGEs）的形成，而晚期糖基化终末产物与氧化应激有关。我们推测，在合并子痫前期或糖尿病的妊娠中会发现血清AGE升高。
方法
对研究患者的循环AGEs、8-异前列腺素、维生素E和抗氧化能力进行分析。
结果
与对照组相比，1型糖尿病患者和妊娠期糖尿病患者的血清AGE升高，但子痫前期患者未升高。与对照组相比，1型糖尿病患者和子痫前期患者的8-异前列腺素升高。
结论
在合并子痫前期或糖尿病的妊娠中，AGEs和8-异前列腺素并非平行升高，提示存在生物学异质性。
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