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通过整合模拟移动床技术实现扩张床吸附的创新。

Innovation of Expanded-Bed Adsorption by Integrating Simulated Moving-Bed Technology.

作者信息

Pathapati Trinath, Rutze Dennis N, de Wit Pieter, den Boer Piet, Zaalberg Menne

机构信息

Xendo B.V. Bio Science Park, Schipholweg 73-75 2316 ZL Leiden The Netherlands.

出版信息

Chem Eng Technol. 2018 Dec;41(12):2393-2401. doi: 10.1002/ceat.201800293. Epub 2018 Oct 30.

DOI:10.1002/ceat.201800293
PMID:31007406
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6472582/
Abstract

Bio-based industries need efficient downstream solutions to process complex streams. This was addressed through a technology integration approach, where expanded-bed adsorption (EBA) is integrated with simulated moving-bed (SMB) technology. Current work involved adaptation of an SMB apparatus and control principle to implement expanded-bed level control. As an outcome, EBA-SMB technology was successfully applied for purification of -aminobutyric acid (GABA). This resulted in two-fold increase in productivity and a GABA purity ≥ 92 % in one step from unclarified fermentation broth, compared to ≥ 93 % purity in case of clarified broth and packed-bed SMB. These results proved that EBA-SMB technology is able to enhance process efficiency and economics of bioprocesses.

摘要

生物基产业需要高效的下游解决方案来处理复杂的物流。这通过一种技术集成方法得以解决，即将膨胀床吸附（EBA）与模拟移动床（SMB）技术相结合。当前的工作包括对SMB装置和控制原理进行改造，以实现膨胀床液位控制。结果，EBA-SMB技术成功应用于γ-氨基丁酸（GABA）的纯化。与澄清肉汤和填充床SMB情况下≥93%的纯度相比，这使得生产率提高了两倍，并且从未澄清的发酵肉汤中一步获得的GABA纯度≥92%。这些结果证明，EBA-SMB技术能够提高生物过程的工艺效率和经济性。

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