Halperin Abigail C, McAfee Timothy A, Jack Lisa M, Catz Sheryl L, McClure Jennifer B, Deprey T Mona, Richards Julie, Zbikowski Susan M, Swan Gary E
University of Washington, Seattle, 1107 NE 45th Street, Suite 345, Seattle, WA 98105, USA.
J Subst Abuse Treat. 2009 Jun;36(4):428-34. doi: 10.1016/j.jsat.2008.09.001. Epub 2008 Nov 11.
This article examines reported symptoms, nonsmoking rates, and medication use among 1,018 smokers using varenicline in a randomized trial comparing three forms of behavioral support for smoking cessation (phone, Web, or phone + Web). One month after beginning varenicline, 168 people (17%) had discontinued the medication. Most (53%) quit due to side effects and other symptoms. The most common side effect among all users was nausea (reported by 57% of users). At 1 month post medication initiation, those not taking varenicline were more likely to report smoking than those who continued the medication (57% vs. 16%, p < .001). Women reported more symptoms but did not discontinue medication at higher rates. Participants who received any telephone counseling (n = 681) were less likely to discontinue their medication than those with Web support only (15% vs. 21%, p < .01). Counseling may improve tolerance of this medication and reduce the rate of discontinuation due to side effects.
本文在一项随机试验中，研究了1018名使用伐尼克兰的吸烟者的报告症状、戒烟率和药物使用情况，该试验比较了三种戒烟行为支持方式（电话、网络或电话+网络）。开始使用伐尼克兰一个月后，168人（17%）停止了用药。大多数人（53%）因副作用和其他症状而停药。所有使用者中最常见的副作用是恶心（57%的使用者报告有此症状）。在开始用药1个月时，未服用伐尼克兰的人比继续用药的人更有可能报告仍在吸烟（57%对16%，p<0.001）。女性报告的症状更多，但停药率并不更高。接受任何电话咨询的参与者（n=681）比仅接受网络支持的参与者停药的可能性更小（15%对21%，p<0.01）。咨询可能会提高对这种药物的耐受性，并降低因副作用而停药的发生率。
