Gallagher Thomas Q, Derkay Craig S
Department of Otolaryngology - Head and Neck Surgery, Naval Medical Center, Portsmouth, USA.
Curr Opin Otolaryngol Head Neck Surg. 2008 Dec;16(6):536-42. doi: 10.1097/MOO.0b013e328316930e.
Recurrent respiratory papillomatosis (RRP) is the most common benign neoplasm of the larynx in children. Over the past several years some exciting new therapeutic options as well as some relevant research into the disease process has emerged that may offer new insight and methods in managing this frustrating disease.
Recent investigations have resulted in the following findings: more accurate prevalence estimates of human papilloma virus in women in the United States; correlation of socioeconomic status and disease severity; the malignant potential of human papilloma virus in head and neck cancer; the role of the host immune system in RRP; the efficacy of a vaccine preventing human papilloma virus; the emergence of pulsed dye laser and potassium-titanyl-phosphate laser as a therapy for RRP; the efficacy of cidofovir as an adjunctive therapy for RRP; and the role of cyclooxygenase-2 in the molecular biology of RRP.
The management of RRP is ever evolving. Despite several new therapies discussed in this study, it is still a disease with the potential for high morbidity. As the focus of therapy shifts from treatment to prevention, it will take many years to determine whether prevention strategies are effective in limiting the spread of this disease. In the mean time, further research is needed to gain better control of this disease process.
复发性呼吸道乳头状瘤病（RRP）是儿童最常见的喉部良性肿瘤。在过去几年中，出现了一些令人兴奋的新治疗选择以及对该疾病进程的一些相关研究，这可能为管理这种令人沮丧的疾病提供新的见解和方法。
最近的研究得出了以下结果：对美国女性人乳头瘤病毒患病率的更准确估计；社会经济地位与疾病严重程度的相关性；人乳头瘤病毒在头颈癌中的恶性潜能；宿主免疫系统在RRP中的作用；预防人乳头瘤病毒疫苗的疗效；脉冲染料激光和磷酸钛氧钾激光作为RRP治疗方法的出现；西多福韦作为RRP辅助治疗的疗效；以及环氧合酶-2在RRP分子生物学中的作用。
RRP的管理在不断发展。尽管本研究讨论了几种新疗法，但它仍然是一种具有高发病率潜力的疾病。随着治疗重点从治疗转向预防，确定预防策略是否能有效限制该疾病的传播需要很多年。与此同时，需要进一步研究以更好地控制这一疾病进程。
