由氯化钯催化的2-炔基苯胺与异氰酸酯的串联加成-环化反应。
Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isocyanates catalyzed by PdCl2.
作者信息
Ye Shengqing, Ding Qiuping, Wang Zhiyong, Zhou Haibo, Wu Jie
机构信息
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.
出版信息
Org Biomol Chem. 2008 Dec 7;6(23):4406-12. doi: 10.1039/b812015c. Epub 2008 Oct 15.
DOI:10.1039/b812015c
PMID:19005601
Abstract
Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isocyanates catalyzed by palladium chloride are described. This reaction is performed in the presence of 10 mol% of palladium chloride in THF at 80 degrees C, which provides an efficient and practical route for the synthesis of 1,2-disubstituted indoles.
摘要
描述了氯化钯催化的2-炔基苯胺与异氰酸酯的串联加成-环化反应。该反应在四氢呋喃中，于80℃、10mol%氯化钯存在的条件下进行，为1,2-二取代吲哚的合成提供了一条高效且实用的路线。
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