解决椎间盘源性疼痛。
Resolving discogenic pain.
作者信息
Takahashi Kazuhisa, Aoki Yasuchika, Ohtori Seiji
机构信息
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoku, Chiba, Chiba, 260-8677, Japan.
出版信息
Eur Spine J. 2008 Dec;17 Suppl 4(Suppl 4):428-31. doi: 10.1007/s00586-008-0752-4. Epub 2008 Nov 13.
Abstract
Recent basic science studies on discogenic low back pain have provided new knowledge about this condition. This paper reviews some of these results and presents an overview of the following findings. The rat lumbar intervertebral disk may be innervated non-segmentally through the paravertebral sympathetic nerve and segmentally through the sinuvertebral nerves, and also by dichotomizing sensory fibers. The exposure of the nucleus pulposus (NP) to the outer annulus fibrosus (AF) may induce nerve injury and ingrowth into the disk. Nerve growth factor (NGF)-sensitive neurons are predominant in the rat intervertebral disk, which indicates that hyperalgesic responses can be induced by inflammation. NGF in the NP may promote axonal growth. Lumbar fusion may inhibit nerve ingrowth into the degenerated disk and reduce the percentage of calcitonin gene related peptide (CGRP)-positive neurons.
摘要
近期关于椎间盘源性下腰痛的基础科学研究为这种疾病提供了新知识。本文回顾了其中一些研究结果，并概述了以下发现。大鼠腰椎间盘可能通过椎旁交感神经非节段性地接受神经支配，通过窦椎神经节段性地接受神经支配，并且也通过感觉纤维的二分法接受神经支配。髓核（NP）暴露于纤维环外层（AF）可能会导致神经损伤并长入椎间盘。神经生长因子（NGF）敏感神经元在大鼠椎间盘中占主导地位，这表明炎症可诱导痛觉过敏反应。NP中的NGF可能促进轴突生长。腰椎融合术可能会抑制神经长入退变的椎间盘，并降低降钙素基因相关肽（CGRP）阳性神经元的比例。
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本文引用的文献
1
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J Bone Joint Surg Br. 2007 Sep;89(9):1135-9. doi: 10.1302/0301-620X.89B9.18939.
2
Nerve fiber ingrowth into scar tissue formed following nucleus pulposus extrusion in the rabbit anular-puncture disc degeneration model: effects of depth of puncture.兔环状穿刺椎间盘退变模型中髓核挤出后形成的瘢痕组织内神经纤维长入：穿刺深度的影响
Spine (Phila Pa 1976). 2006 Oct 1;31(21):E774-80. doi: 10.1097/01.brs.0000238681.71537.41.
3
Exposure of the nucleus pulposus to the outside of the anulus fibrosus induces nerve injury and regeneration of the afferent fibers innervating the lumbar intervertebral discs in rats.髓核暴露于纤维环外部会导致大鼠腰间盘传入纤维的神经损伤和再生。
Spine (Phila Pa 1976). 2006 Jun 1;31(13):1433-8. doi: 10.1097/01.brs.0000219946.25103.db.
4
Innervation of the lumbar intervertebral disc by nerve growth factor-dependent neurons related to inflammatory pain.与炎性疼痛相关的神经生长因子依赖性神经元对腰椎间盘的神经支配。
Spine (Phila Pa 1976). 2004 May 15;29(10):1077-81. doi: 10.1097/00007632-200405150-00005.
5
Nerve growth factor expression and innervation of the painful intervertebral disc.神经生长因子在疼痛性椎间盘的表达及神经支配
J Pathol. 2002 Jul;197(3):286-92. doi: 10.1002/path.1108.
6
Sensory innervation of the dorsal portion of the lumbar intervertebral disc in rats.大鼠腰椎间盘背侧的感觉神经支配
Spine (Phila Pa 1976). 1999 Nov 15;24(22):2295-9. doi: 10.1097/00007632-199911150-00002.
7
Innervation of "painful" lumbar discs.“疼痛性”腰椎间盘的神经支配
Spine (Phila Pa 1976). 1997 Oct 15;22(20):2342-9; discussion 2349-50. doi: 10.1097/00007632-199710150-00005.
8
Nerve ingrowth into diseased intervertebral disc in chronic back pain.神经长入慢性背痛患者的病变椎间盘。
Lancet. 1997 Jul 19;350(9072):178-81. doi: 10.1016/s0140-6736(97)02135-1.
9
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Br J Pharmacol. 1997 Jun;121(3):417-24. doi: 10.1038/sj.bjp.0701148.
10
Sensory innervation to the anterior portion of lumbar intervertebral disc.
Spine (Phila Pa 1976). 1996 Aug 15;21(16):1848-51. doi: 10.1097/00007632-199608150-00002.
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