Hartmann A, Dettmers C, Schuier F J, Wassmann H D, Schumacher H W
Neurologische Universitätsklinik, Bonn, FRG.
Stroke. 1991 Feb;22(2):182-9. doi: 10.1161/01.str.22.2.182.
We evaluated the effects of breathing 35% stable xenon in 65% oxygen on regional cerebral blood flow and the electroencephalogram in 20 normal volunteers. We measured blood flow in 32 brain regions over both hemispheres with the xenon-133 intravenous injection technique in two protocols. In the first protocol (n = 10), a baseline study was followed by a second study during 5 minutes of breathing stable xenon; in the other protocol (n = 8), the baseline study was followed by a second study after 5 minutes of breathing stable xenon. Two volunteers were excluded due to excessive movements during the inhalation of stable xenon. Some of the remaining 18 volunteers had varying alterations of consciousness accompanied by electroencephalogram changes. After stable xenon inhalation the electroencephalogram returned to normal within 2-3 minutes. During stable xenon inhalation mean +/- SD PECO2 dropped significantly from 39.4 +/- 4.4 to 33.3 +/- 5.4 mm Hg in the first protocol and from 39.4 +/- 2.6 to 34.8 +/- 4.1 mm Hg in the second protocol due to hyperventilation in 13 volunteers. Mean regional cerebral blood flow increased significantly by 13.5-25.4% without correction for PECO2. In the first protocol regional cerebral blood flow increased by greater than 12% in 11-14 (depending on the flow parameter) of the 20 hemispheres. In the second protocol regional cerebral blood flow increased by greater than 12% in 9-13 of the 16 hemispheres. We conclude that cautious interpretation is necessary in the assessment of regional cerebral blood flow with 35% xenon-enhanced computed tomography.
我们评估了20名正常志愿者吸入含35%稳定氙气和65%氧气的混合气体对局部脑血流量和脑电图的影响。我们采用两种方案，通过静脉注射氙 - 133技术测量了双侧大脑32个区域的血流量。在第一个方案（n = 10）中，先进行基线研究，然后在吸入稳定氙气5分钟期间进行第二项研究；在另一个方案（n = 8）中，基线研究之后是在吸入稳定氙气5分钟后进行第二项研究。两名志愿者因在吸入稳定氙气期间活动过多而被排除。其余18名志愿者中，一些人出现了意识的不同改变并伴有脑电图变化。吸入稳定氙气后，脑电图在2 - 3分钟内恢复正常。在第一个方案中，由于13名志愿者出现过度通气，吸入稳定氙气期间平均±标准差呼气末二氧化碳分压（PECO2）从39.4±4.4显著降至33.3±5.4 mmHg；在第二个方案中，从39.4±2.6降至34.8±4.1 mmHg。未校正PECO2时，平均局部脑血流量显著增加了13.5% - 25.4%。在第一个方案中，20个半球中有11 - 14个（取决于血流参数）局部脑血流量增加超过12%。在第二个方案中，16个半球中有9 - 13个局部脑血流量增加超过12%。我们得出结论，在使用35%氙增强计算机断层扫描评估局部脑血流量时，必须谨慎解读结果。
