Hartmann A, Wassman H, Czernicki Z, Dettmers C, Schumacher H W, Tsuda Y
Stroke. 1987 May-Jun;18(3):643-8. doi: 10.1161/01.str.18.3.643.
Measurement of regional cerebral blood flow (rCBF) was performed in 6 healthy baboons during ventilation with 35% stable xenon in artificial air. rCBF was measured with the intraarterial xenon-133 method. EEG was recorded continuously. All CBF areas of interest over one hemisphere reacted in the same way. Mean flow increased during short-term exposure to stable xenon and decreased if stable xenon inhalation was continued for at least 24 minutes. EEG showed a decrease of alpha- and beta-wave patterns a short time after the start of stable xenon inhalation without further changes over the period when rCBF finally decreased. CO2 reactivity increased in most animals, and autoregulation to mild arterial hypotension was significantly impaired with increased flow. It is concluded that 35% stable xenon in artificial air increases rCBF after short-term exposure and decreases rCBF after longer exposure. EEG changes were noted after short-term exposure. rCBF and EEG recovered rapidly after the end of stable xenon inhalation.
在6只健康狒狒吸入含35%稳定氙的人工空气进行通气期间，采用动脉内注入氙-133的方法测量局部脑血流量（rCBF）。同时持续记录脑电图（EEG）。一个半球上所有感兴趣的脑血流量区域反应方式相同。短期接触稳定氙时平均血流量增加，而如果持续吸入稳定氙至少24分钟，则血流量下降。脑电图显示，在开始吸入稳定氙后短时间内α波和β波模式减少，而在局部脑血流量最终下降的期间内没有进一步变化。大多数动物的二氧化碳反应性增加，并且随着血流量增加，对轻度动脉低血压的自动调节功能明显受损。得出的结论是，吸入含35%稳定氙的人工空气在短期接触后会增加局部脑血流量，而在较长时间接触后会降低局部脑血流量。短期接触后可观察到脑电图变化。在停止吸入稳定氙后，局部脑血流量和脑电图迅速恢复。
