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本文引用的文献

1
Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication.Thy-1与αVβ3整合素的直接相互作用介导神经元与星形胶质细胞间的通讯。
Biochim Biophys Acta. 2008 Jun;1783(6):1111-20. doi: 10.1016/j.bbamcr.2008.01.034. Epub 2008 Feb 20.
2
Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system.用于在神经系统中组合表达荧光蛋白的转基因策略。
Nature. 2007 Nov 1;450(7166):56-62. doi: 10.1038/nature06293.
3
Transient anchorage of cross-linked glycosyl-phosphatidylinositol-anchored proteins depends on cholesterol, Src family kinases, caveolin, and phosphoinositides.交联糖基磷脂酰肌醇锚定蛋白的瞬时锚定取决于胆固醇、Src家族激酶、小窝蛋白和磷酸肌醇。
J Cell Biol. 2006 Oct 9;175(1):169-78. doi: 10.1083/jcb.200512116.
4
Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I.Thy-1 通过其糖基磷脂酰肌醇（GPI）锚定物，响应血小板反应蛋白-1/肝配蛋白 I，调节Src家族激酶和粘着斑激酶的磷酸化及亚细胞定位，以及成纤维细胞迁移。
Exp Cell Res. 2006 Nov 15;312(19):3752-67. doi: 10.1016/j.yexcr.2006.07.029. Epub 2006 Sep 12.
5
Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses.Thy-1，一种影响细胞黏附、增殖、存活及细胞因子/生长因子反应的信号传导多功能调节剂。
Biochim Biophys Acta. 2006 Oct;1763(10):991-9. doi: 10.1016/j.bbamcr.2006.08.008. Epub 2006 Aug 18.
6
Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis.Thy-1作为轴突再生、细胞凋亡、黏附、迁移、癌症和纤维化过程中细胞间及细胞与基质相互作用的调节因子。
FASEB J. 2006 Jun;20(8):1045-54. doi: 10.1096/fj.05-5460rev.
7
Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis.成纤维细胞Thy-1表达缺失与肺纤维化相关。
Am J Pathol. 2005 Aug;167(2):365-79. doi: 10.1016/S0002-9440(10)62982-3.
8
Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium.人Thy-1（CD 90）与整合素αvβ3（CD51/CD61）的相互作用：介导黑色素瘤细胞黏附于活化内皮细胞的重要机制。
Oncogene. 2005 Jul 7;24(29):4710-20. doi: 10.1038/sj.onc.1208559.
9
Characterization of alphaX I-domain binding to Thy-1.αX I结构域与Thy-1结合的特性分析
Biochem Biophys Res Commun. 2005 Jun 3;331(2):557-61. doi: 10.1016/j.bbrc.2005.04.006.
10
Thy-1: more than a mouse pan-T cell marker.Thy-1：不仅仅是一种小鼠全T细胞标志物。
J Immunol. 2004 Sep 15;173(6):3581-8. doi: 10.4049/jimmunol.173.6.3581.

掌握Thy-1信号传导

Getting a grip on Thy-1 signaling.

作者信息

Barker Thomas H, Hagood James S

机构信息

Biomedical Engineering, GA Tech/Emory, 313 Ferst Drive, Ste 3111 Atlanta, GA 30332-0535, USA.

出版信息

Biochim Biophys Acta. 2009 May;1793(5):921-3. doi: 10.1016/j.bbamcr.2008.10.004. Epub 2008 Oct 25.

DOI:10.1016/j.bbamcr.2008.10.004
PMID:19007822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2701903/
Abstract

A recent study by Hermosilla et al. [T. Hermosilla, D. Munoz, R. Herrera-Molina, A. Valdivia, N. Munoz, S.U. Nham, P. Schneider, K. Burridge, A.F. Quest, L. Leyton, Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication, Biochim Biophys Acta 1783 (2008) 1111-1120] demonstrates that Thy-1 on neurons binds to alphavbeta3 integrin on astrocytes via a conserved RLD motif, triggering the formation of focal adhesions and stress fibers via tyrosine phosphorylation and RhoA activation. This study adds to growing evidence regarding the signaling mechanisms and biological roles of Thy-1, an important regulator of context-dependent signaling. As knowledge of Thy-1 approaches its fiftieth year, it is critical to begin to synthesize insights from different fields to determine how this heretofore enigmatic molecule modulates cell behavior in both cis and trans.

摘要

赫莫西利亚等人近期的一项研究[蒂莫西·赫莫西利亚、迭戈·穆尼奥斯、罗德里戈·埃雷拉 - 莫利纳、阿尔贝托·瓦尔迪维亚、娜塔利娅·穆尼奥斯、苏·恩哈姆、彼得·施奈德、凯西·伯里奇、A.F. 奎斯特、莱昂纳多·莱顿，“Thy - 1/αVβ3整合素直接相互作用介导神经元与星形胶质细胞通讯”，《生物化学与生物物理学报》1783 (2008) 1111 - 1120]表明，神经元上的Thy - 1通过保守的RLD基序与星形胶质细胞上的αVβ3整合素结合，通过酪氨酸磷酸化和RhoA激活触发粘着斑和应力纤维的形成。这项研究进一步证明了关于Thy - 1的信号传导机制和生物学作用的证据不断增加，Thy - 1是一种依赖于环境的信号传导的重要调节因子。随着对Thy - 1的研究接近五十周年，至关重要的是开始整合来自不同领域的见解，以确定这个迄今为止神秘的分子如何在顺式和反式中调节细胞行为。