McLaughlin-Drubin Margaret E, Münger Karl
Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Virology. 2009 Feb 20;384(2):335-44. doi: 10.1016/j.virol.2008.10.006. Epub 2008 Nov 12.
The human papillomavirus (HPV) E7 oncoprotein shares functional similarities with such proteins as adenovirus E1A and SV40 large tumor antigen. As one of only two viral proteins always expressed in HPV-associated cancers, E7 plays a central role in both the viral life cycle and carcinogenic transformation. In the HPV viral life cycle, E7 disrupts the intimate association between cellular differentiation and proliferation in normal epithelium, allowing for viral replication in cells that would no longer be in the dividing population. This function is directly reflected in the transforming activities of E7, including tumor initiation and induction of genomic instability.
人乳头瘤病毒（HPV）E7癌蛋白与腺病毒E1A和SV40大肿瘤抗原等蛋白质具有功能相似性。作为仅在HPV相关癌症中始终表达的两种病毒蛋白之一，E7在病毒生命周期和致癌转化中均起着核心作用。在HPV病毒生命周期中，E7破坏了正常上皮细胞中细胞分化与增殖之间的紧密联系，使得病毒能够在不再处于分裂群体的细胞中进行复制。该功能直接反映在E7的转化活性中，包括肿瘤起始和基因组不稳定性的诱导。
