Michelsen Trond M, Pripp Are H, Tonstad Serena, Tropé Claes G, Dørum Anne
Department of Gynaecology, Sørlandet Hospital Arendal, Arendal, Norway.
Eur J Cancer. 2009 Jan;45(1):82-9. doi: 10.1016/j.ejca.2008.09.028. Epub 2008 Nov 12.
Surgical menopause may increase the risk of cardiovascular diseases (CVDs). The aim of this study was to determine the risk of metabolic syndrome in women who had undergone risk-reducing salpingo-oophorectomy (RRSO) because of increased risk of hereditary breast ovarian cancer (HBOC). A sample of 326 (65% of invited) women at risk of HBOC who had undergone RRSO was compared to 679 women from the general population. Mean follow-up after surgery was 6.5 years (standard deviations [SD] 4.4). RRSO was significantly associated with metabolic syndrome according to the 2005 National Cholesterol Education Program Adult Treatment Panel III criteria (odds ratio [OR] 2.46 [95% confidence interval (CI) 1.63, 3.73]) and according to the International Diabetes Federation criteria (OR 2.49 [CI 1.60, 3.88]), as were increasing age and body mass index (BMI). RRSO in women at risk of HBOC is significantly associated with the metabolic syndrome, and the follow-up after RRSO should take these findings into consideration.
手术绝经可能会增加心血管疾病（CVDs）的风险。本研究的目的是确定因遗传性乳腺癌卵巢癌（HBOC）风险增加而接受预防性输卵管卵巢切除术（RRSO）的女性患代谢综合征的风险。将326名（占受邀者的65%）有HBOC风险且接受了RRSO的女性样本与679名来自普通人群的女性进行了比较。术后平均随访时间为6.5年（标准差[SD]4.4）。根据2005年美国国家胆固醇教育计划成人治疗小组III标准（优势比[OR]2.46[95%置信区间（CI）1.63，3.73]）以及国际糖尿病联盟标准（OR 2.49[CI 1.60，3.88]），RRSO与代谢综合征显著相关，年龄增长和体重指数（BMI）增加也与之显著相关。有HBOC风险的女性接受RRSO与代谢综合征显著相关，RRSO后的随访应考虑这些发现。
