Ellins Elizabeth, Shamaei-Tousi Alireza, Steptoe Andrew, Donald Ann, O'Meagher Shamus, Halcox Julian, Henderson Brian
Vascular Physiology Unit, Institute of Child Health, University College London, UK.
J Hypertens. 2008 Dec;26(12):2389-92. doi: 10.1097/HJH.0b013e328313918b.
There is growing evidence that the presence of the cell stress protein heat shock protein (HSP) 60 in the circulation is associated with risk of coronary heart disease. In this study, we measured the association between plasma HSP60 and carotid arterial stiffness in middle-aged men and women.
Six hundred and forty-seven men and women aged 50-72 years and free of cardiovascular disease and medication were tested. Carotid artery distensibility coefficient was assessed ultrasonically as a measure of arterial stiffness, and plasma HSP60 was assessed using a sensitive immunoassay.
We found a significant, independent association between high plasma levels of HSP60 and increased carotid stiffness. Carotid distensibility coefficient was also related to diabetes, adiposity, blood pressure, lipids, plasma interleukin-6 and C-reactive protein. After adjusting for these factors, the odds of HSP60 concentration of at least 1000 ng/ml were 1.79 (95% confidence intervals 1.06-3.04) for participants in the lowest compared with the highest tertile of the distensibility coefficient.
HSP60 is a potent activator of vascular endothelial cells and smooth muscle cells. Thus, it is possible that long-term stimulation of these cell populations by blood-borne HSP60 acts to drive blood vessel changes resulting in decreased arterial elasticity.
越来越多的证据表明，循环中的细胞应激蛋白热休克蛋白（HSP）60与冠心病风险相关。在本研究中，我们测量了中年男性和女性血浆HSP60与颈动脉僵硬度之间的关联。
对647名年龄在50 - 72岁、无心血管疾病且未服用药物的男性和女性进行了检测。通过超声评估颈动脉扩张系数作为动脉僵硬度的指标，并使用灵敏的免疫测定法评估血浆HSP60。
我们发现血浆HSP60水平升高与颈动脉僵硬度增加之间存在显著的独立关联。颈动脉扩张系数还与糖尿病、肥胖、血压、血脂、血浆白细胞介素 - 6和C反应蛋白有关。在对这些因素进行调整后，与扩张系数最高三分位数的参与者相比，扩张系数最低三分位数的参与者血浆HSP60浓度至少为1000 ng/ml的比值比为1.79（95%置信区间1.06 - 3.04）。
HSP60是血管内皮细胞和平滑肌细胞的强效激活剂。因此，血源性HSP60对这些细胞群体的长期刺激可能会导致血管变化，从而使动脉弹性降低。
