Leimann Beatriz Consuelo Quinet, Koifman Rosalina Jorge
Laboratório de Microbiologia/Micologia, Instituto Estadual de Infectologia São Sebastião, Rio de Janeiro, Brasil.
Cad Saude Publica. 2008 Nov;24(11):2582-92. doi: 10.1590/s0102-311x2008001100013.
The objective of this article was to evaluate the epidemiology of cryptococcal meningitis in Rio de Janeiro State, Brazil, from 1994 to 2004. Six hundred and ninety-six cases of cryptococcal meningitis were reported, with a mean incidence of 0.45 per 100,000 inhabitants. Patients were predominantly male; mean age was 35.9 years; AIDS was practically the only underlying disease, reported in 61.2% of cases; case-fatality was 51.8%. No decline in incidence was observed during the study period. AIDS is the main predisposing condition for cryptococcal meningitis, and thus the profile of most patients mirrors that of HIV infection. Missing information prevented the evaluation of other underlying diseases.
本文的目的是评估1994年至2004年巴西里约热内卢州隐球菌性脑膜炎的流行病学情况。共报告了696例隐球菌性脑膜炎病例，平均发病率为每10万居民0.45例。患者以男性为主；平均年龄为35.9岁；艾滋病几乎是唯一的基础疾病，61.2%的病例报告患有艾滋病；病死率为51.8%。在研究期间未观察到发病率下降。艾滋病是隐球菌性脑膜炎的主要诱发因素，因此大多数患者的情况反映了艾滋病毒感染的情况。信息缺失妨碍了对其他基础疾病的评估。
