Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas-HEMOAM, Manaus, AM, Brazil.
Universidade do Estado do Amazonas-UEA, Manaus, AM, Brazil.
Ann Clin Microbiol Antimicrob. 2020 May 20;19(1):20. doi: 10.1186/s12941-020-00361-3.
Cryptococcosis is a disease of wide geographic distribution. It is most critical when it affects immunocompromised patients, with AIDS, tuberculosis or other diseases that require prolonged hospitalization.
This study described a case report, molecular epidemiology, the phylogenetic relationship, along with antifungal susceptibility test of a new ST 623 of C. neoformans isolated in a patient with non-Hodgkin's Lymphoma, from Manaus, Brazil.
The new C. neoformans was susceptible to all antifungal drugs tested. Our results showed that ST623 new clone has no evident evolutionary proximity to any other ST of the VNI subtype group identified in Brazil.
In the context of phylogenetic analysis, this new genotype belongs to VNI subtype, and subsequencing complete genome studies are necessary to better understand the phylogenetic relationships amongst STs in this group.
cryptococcosis 是一种分布广泛的疾病。当它影响免疫功能低下的患者，如艾滋病、结核病或其他需要长期住院的疾病时，情况就变得尤为严重。
本研究描述了巴西马瑙斯市的一名非霍奇金淋巴瘤患者中新分离的 C. neoformans 型 623 株的病例报告、分子流行病学、系统发育关系以及抗真菌药敏试验。
新型 C. neoformans 对所有测试的抗真菌药物均敏感。我们的结果表明，新的 ST623 克隆与在巴西鉴定的 VNI 亚型组的任何其他 ST 没有明显的进化关系。
在系统发育分析的背景下，这种新的基因型属于 VNI 亚型，需要进行完整基因组测序研究，以更好地了解该组中 ST 之间的系统发育关系。
