Poyrazoglu Orhan Kursat, Bahcecioglu Ibrahim Halil, Ataseven Huseyin, Metin Kerem, Dagli Adile Ferda, Yalniz Mehmet, Ustundag Bilal
Division of Gastroenterology, School of Medicine, Firat University, Elazig, Turkey.
Inflammation. 2008 Dec;31(6):408-13. doi: 10.1007/s10753-008-9092-0.
To assess the role of unfiltered coffee upon carbon tetrachloride (CCl(4)) induced hepatotoxicity in rats. All rats were randomly divided into control group, CCl(4)-treated, unfiltered coffee-treated and CCl(4)/unfiltered coffee-treated. Hepatic damage was induced by repeated intraperitoneal injections of CCl(4) every other day. Unfiltered coffee was given as drinking fluid for 8 days starting the day before CCl(4) administration. Liver enzymes, plasma and liver tissue malondialdehyde were analyzed. Histopathological evaluation of liver sections was performed. Serum aminotransferase level significantly increased in CCl(4)/unfiltered coffee-treated group compared to CCl(4)-treated group, as well as, lipid peroxidation products in the plasma and liver tissue. In addition, histopathological findings including inflammation and necrosis were significantly confirmed these findings. Unfiltered coffee potentiates acute liver injury in rats with CCl(4)-induced hepatotoxicity.
评估未过滤咖啡对四氯化碳（CCl₄）诱导的大鼠肝毒性的作用。所有大鼠随机分为对照组、CCl₄处理组、未过滤咖啡处理组和CCl₄/未过滤咖啡处理组。每隔一天通过腹腔注射CCl₄诱导肝损伤。从CCl₄给药前一天开始，将未过滤咖啡作为饮用水给予8天。分析肝酶、血浆和肝组织丙二醛。对肝切片进行组织病理学评估。与CCl₄处理组相比，CCl₄/未过滤咖啡处理组的血清氨基转移酶水平显著升高，血浆和肝组织中的脂质过氧化产物也是如此。此外，包括炎症和坏死在内的组织病理学发现显著证实了这些结果。未过滤咖啡会增强CCl₄诱导肝毒性的大鼠的急性肝损伤。
