使用抗IgE抗体（奥马珠单抗）治疗囊性纤维化（CF）中的过敏性支气管肺曲霉病（ABPA）。

Treatment of allergic bronchopulmonary aspergillosis (ABPA) in CF with anti-IgE antibody (omalizumab).

作者信息

Kanu Adaobi, Patel Kalpana

机构信息

Division of Pediatric Pulmonology, Texas Tech University, Health Sciences Center, Lubbock, Texas 79430, USA.

出版信息

Pediatr Pulmonol. 2008 Dec;43(12):1249-51. doi: 10.1002/ppul.20907.

DOI:10.1002/ppul.20907

PMID:19009619

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) results from IgE induced pulmonary response to aspergillus species. Recognition and management of ABPA is challenging in cystic fibrosis (CF) patients because changes in symptoms, lung function and chest radiograph are similar to that seen in CF related pulmonary infection. Standard therapy for ABPA includes systemic steroids and adjunctive use of antifungal agents. Little has been published regarding the use of monoclonal anti-IgE antibody in those with ABPA. We report a CF patient with her third exacerbation of ABPA who was treated with monoclonal anti-IgE (omalizumab) antibody; she had unfavorable side effects with prednisone therapy. This therapy resulted in improvement of pulmonary symptoms and lung function not achieved with antibiotics or prednisone alone.

摘要

变应性支气管肺曲霉病（ABPA）是由IgE介导的肺部对曲霉属物种的反应所致。在囊性纤维化（CF）患者中，ABPA的识别和管理具有挑战性，因为症状、肺功能和胸部X线片的变化与CF相关肺部感染所见相似。ABPA的标准治疗包括全身用类固醇和抗真菌药物的辅助使用。关于在ABPA患者中使用单克隆抗IgE抗体的报道很少。我们报告了一名ABPA第三次加重的CF患者，该患者接受了单克隆抗IgE（奥马珠单抗）抗体治疗；她使用泼尼松治疗时出现了不良副作用。这种治疗改善了肺部症状和肺功能，而单独使用抗生素或泼尼松无法达到这样的效果。