Kuratsu J, Seto H, Kochi M, Itoyama Y, Uemura S, Ushio Y
Department of Neurosurgery, Kumamoto University Medical School, Japan.
Surg Neurol. 1991 Apr;35(4):305-9. doi: 10.1016/0090-3019(91)90010-7.
Two patients with metastatic angiosarcoma of the brain are described. In one, a 17-year-old man, the tumor was located at the pineal region and exhibited significant vascularity. It was sensitive to radiation therapy and disappeared after radiation of 50 Gy; however, it recurred after 1 year and a new lesion was found in the liver. The other patient is a 31-year-old woman who experienced sudden onset of headache. Computed tomography scan revealed three separate masses in the brain. One tumor was surgically removed. The other two were sensitive to radiation therapy and disappeared after radiation of 40 Gy. A new lesion was found in the femur 16 months after the operation. Brain metastasis from angiosarcoma is exceedingly rare. Both patients developed symptoms with intracranial hemorrhage. The diagnosis of the metastatic lesions preceded diagnosis of the primary lesion by 12 and 16 months, respectively. Ulex europaeus 1 lectin and factor VIII were very useful in establishing the diagnosis of angiosarcoma.
本文描述了两名患有脑转移性血管肉瘤的患者。其中一名是17岁男性，肿瘤位于松果体区，血管丰富。该肿瘤对放射治疗敏感，接受50 Gy放疗后消失；然而，1年后复发，肝脏出现新病灶。另一名患者是31岁女性，突然出现头痛。计算机断层扫描显示脑内有三个独立肿块。其中一个肿瘤通过手术切除。另外两个对放射治疗敏感，接受40 Gy放疗后消失。术后16个月在股骨发现新病灶。血管肉瘤脑转移极为罕见。两名患者均出现颅内出血症状。转移病灶的诊断分别比原发病灶的诊断早12个月和16个月。荆豆凝集素1和因子VIII对血管肉瘤的诊断非常有用。
