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卵巢衰老、卵泡耗竭与癌症：一种涉及卵泡耗竭的上皮性卵巢癌病因假说

Ovarian ageing, follicle depletion, and cancer: a hypothesis for the aetiology of epithelial ovarian cancer involving follicle depletion.

作者信息

Smith Elizabeth R, Xu Xiang-Xi

机构信息

Department of Medicine, University of Miami School of Medicine, Miami, FL, USA.

出版信息

Lancet Oncol. 2008 Nov;9(11):1108-11. doi: 10.1016/S1470-2045(08)70281-X.

DOI:10.1016/S1470-2045(08)70281-X
PMID:19012860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2713057/
Abstract

The association between ovarian cancer risk and reproductive factors has been well established, and two main theories, incessant ovulation and gonadotropin stimulation, have been proposed to explain the mechanism. Recent studies using animal models of ovarian tumorigenesis, and analysis of ovarian tissues from prophylactic oophorectomies, suggest that depletion of ovarian follicles might underlie the epidemiological findings linking reproductive history and ovarian cancer risk.

摘要

卵巢癌风险与生殖因素之间的关联已得到充分证实，并且已经提出了两个主要理论，即持续排卵和促性腺激素刺激，来解释其机制。最近使用卵巢肿瘤发生动物模型的研究以及对预防性卵巢切除术的卵巢组织分析表明，卵巢卵泡的耗竭可能是将生殖史与卵巢癌风险联系起来的流行病学发现的基础。

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Am J Pathol. 2007 Apr;170(4):1325-36. doi: 10.2353/ajpath.2007.060769.
2
Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations.有和没有BRCA突变人群的人类卵巢的年龄依赖性形态学改变。
Gynecol Oncol. 2006 Nov;103(2):719-28. doi: 10.1016/j.ygyno.2006.03.053. Epub 2006 May 12.
3
Analgesic drug use and risk of ovarian cancer.镇痛药的使用与卵巢癌风险
Epidemiology. 2006 Jan;17(1):104-7. doi: 10.1097/01.ede.0000190538.55645.f8.
4
Loss of ovarian function and the risk of ovarian cancer.卵巢功能丧失与卵巢癌风险
Cell Tissue Res. 2005 Oct;322(1):117-24. doi: 10.1007/s00441-005-1100-1. Epub 2005 Nov 3.
5
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6
Endogenous hormones and ovarian cancer: epidemiology and current hypotheses.内源性激素与卵巢癌：流行病学及当前假说
Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):98-107.
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Cancer Res. 2004 Feb 15;64(4):1534-40. doi: 10.1158/0008-5472.can-03-2928.
8
Focus on epithelial ovarian cancer.关注上皮性卵巢癌。
Cancer Cell. 2004 Jan;5(1):19-24. doi: 10.1016/s1535-6108(04)00002-9.
9
A mechanism for cox-2 inhibitor anti-inflammatory activity in chemoprevention of epithelial cancers.
Cancer Epidemiol Biomarkers Prev. 2004 Jan;13(1):144-5. doi: 10.1158/1055-9965.epi-461-2.
10
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