Majka Darcy S, Chang Rowland W, Vu Thanh-Huyen T, Palmas Walter, Geffken Dominic F, Ouyang Pamela, Ni Hanyu, Liu Kiang
Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Am J Prev Med. 2009 Jan;36(1):56-62. doi: 10.1016/j.amepre.2008.09.031. Epub 2008 Nov 17.
Previous studies have suggested an inverse relationship between physical activity and markers of inflammation such as high-sensitivity C-reactive protein (hs-CRP). However, these were inconsistent, and few examined whether race and gender influenced the relationship. This study determined a cross-sectional association between physical activity and hs-CRP level in 6142 middle-aged white, Chinese, black, and Hispanic participants enrolled in the Multi-Ethnic Study of Atherosclerosis in 2000-2002.
Combined moderate and vigorous physical activity was measured by self-reported leisure, conditioning, occupational, and household activities. ANCOVA was used to assess the association between moderate/vigorous physical activity and hs-CRP by gender and race.
Hs-CRP was higher in women. Blacks had the highest hs-CRP, and Chinese participants had the lowest. Hs-CRP decreased across tertiles of moderate/vigorous physical activity in Hispanic men in models adjusted for age, education, study site, and physical activity questionnaire mode of administration (p=0.005) and further adjusted for smoking, infection, and aspirin use (p=0.020). The trend remained significant after further adjustment for BMI; blood pressure; low-density lipoprotein cholesterol; high-density lipoprotein cholesterol; diabetes; and the use of antihypertensive, statin, and diabetes medication (p=0.044). There was a downward trend in hs-CRP across tertiles of physical activity in black and white men, but the association was weaker. No clear trend was observed in any female racial/ethnic groups.
These findings suggest that the association between moderate/vigorous physical activity and hs-CRP differs by race and gender. Further studies are needed to confirm this and to examine the mechanisms for these race and gender differences.
先前的研究表明，体育活动与炎症标志物如高敏C反应蛋白（hs-CRP）之间存在负相关关系。然而，这些研究结果并不一致，而且很少有研究探讨种族和性别是否会影响这种关系。本研究确定了2000年至2002年参加动脉粥样硬化多民族研究的6142名中年白人、华裔、黑人及西班牙裔参与者的体育活动与hs-CRP水平之间的横断面关联。
通过自我报告的休闲、健身、职业和家务活动来测量中度和剧烈体育活动的综合情况。采用协方差分析按性别和种族评估中度/剧烈体育活动与hs-CRP之间的关联。
女性的hs-CRP水平较高。黑人的hs-CRP最高，华裔参与者的hs-CRP最低。在根据年龄、教育程度、研究地点和体育活动问卷管理模式进行调整的模型中，西班牙裔男性的hs-CRP随着中度/剧烈体育活动三分位数的增加而降低（p=0.005），在进一步根据吸烟、感染和阿司匹林使用情况进行调整后（p=0.020），该趋势仍然显著。在进一步根据体重指数、血压、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、糖尿病以及使用抗高血压药、他汀类药物和糖尿病药物进行调整后，该趋势仍然显著（p=0.044）。黑人和白人男性的hs-CRP随着体育活动三分位数的增加呈下降趋势，但这种关联较弱。在任何女性种族/族裔群体中均未观察到明显趋势。
这些发现表明，中度/剧烈体育活动与hs-CRP之间的关联因种族和性别而异。需要进一步研究来证实这一点，并探讨这些种族和性别差异的机制。
