Federal University of Pelotas-Postgraduate Program in Epidemiology, Pelotas, Brazil.
Federal University of Pelotas-Department of Physiology and Pharmacology, Pelotas, Brazil.
PLoS One. 2019 May 9;14(5):e0216202. doi: 10.1371/journal.pone.0216202. eCollection 2019.
The literature on the relationship between lifestyle behaviors and inflammatory markers is scarce.
A birth cohort was followed since birth up to 22 years in Southern Brazil. Interleukin-6 (IL-6), C-reactive protein (CRP) and adiponectin were measured in nonfasting blood samples drawn at 18 and 22 years of age. Exposures including smoking, alcohol intake, physical inactivity and obesity, were collected at 15, 18 and 22 years. Cross sectional analyses were based on the number of follow-up visits with these exposures and the association with IL-6, CRP and adiponectin at 22 years old. We also carried out a longitudinal Generalized Least Squares (GLS) random-effects analysis with outcomes at 18 and at 22 years old. All analyses were adjusted for several covariates.
The sample comprised 3,479 cohort members at 22 years. The presence of obesity at ≥ 2 follow-ups showed the highest mean values (SE) for IL-6 [2.45 (1.05)] and CRP [3.74 (1.11)] and the lowest mean value for adiponectin [8.60 (0.37)] (adjusted analyses, females) compared with other exposures; the highest mean of IL-6 [1.65 (1.05)] and CRP [1.78 (1.11)] and the lowest mean of adiponectin [9.98 (0.38)] were for the number of follow-ups with ≥2 exposures compared to those with no exposures at any follow-up (adjusted analyses, females). The longitudinal analysis showed an increase in obesity associated with IL-6 and CRP in both sexes and an inverse association with adiponectin in females; smoking (in males) was associated with IL-6 and CRP, harmful alcohol intake was associated with CRP in males, and increased in physical activity was inversely associated with CRP in men.
We concluded that obesity is the main exposure positively associated with IL-6 and CRP and inversely associated with adiponectin (mainly in females). Smoking is also associated with these markers in the longitudinal analysis (in males).
关于生活方式行为与炎症标志物之间关系的文献很少。
巴西南部的一个出生队列从出生开始一直随访到 22 岁。在 18 岁和 22 岁时，抽取非禁食血样测量白细胞介素-6（IL-6）、C 反应蛋白（CRP）和脂联素。在 15、18 和 22 岁时收集吸烟、饮酒、身体活动不足和肥胖等暴露情况。基于随访时这些暴露情况的次数进行横断面分析，并与 22 岁时的 IL-6、CRP 和脂联素进行关联分析。我们还对 18 岁和 22 岁的结果进行了广义最小二乘法（GLS）随机效应分析。所有分析均调整了多个协变量。
在 22 岁时，样本由 3479 名队列成员组成。与其他暴露因素相比，≥2 次随访存在肥胖的人（女性）的 IL-6[2.45（1.05）]和 CRP[3.74（1.11）]均值最高，脂联素[8.60（0.37）]均值最低（调整分析）；与任何随访均无暴露的情况相比，有≥2 次随访存在肥胖的人（女性）的 IL-6[1.65（1.05）]和 CRP[1.78（1.11）]均值最高，脂联素[9.98（0.38）]均值最低（调整分析）。纵向分析显示，肥胖在两性中均与 IL-6 和 CRP 呈正相关，与女性的脂联素呈负相关；吸烟（男性）与 IL-6 和 CRP 相关，有害饮酒与男性 CRP 相关，身体活动增加与男性 CRP 呈负相关。
我们的结论是，肥胖是与 IL-6 和 CRP 呈正相关，与脂联素呈负相关的主要暴露因素（主要在女性中）。在纵向分析中，吸烟也与这些标志物相关（在男性中）。
