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1
Administration of oral vitamin D induces cathelicidin production in atopic individuals.口服维生素D可诱导特应性个体产生抗菌肽。
J Allergy Clin Immunol. 2008 Oct;122(4):829-831. doi: 10.1016/j.jaci.2008.08.020.
2
Reduced vitamin D levels in adult subjects with chronic urticaria.慢性荨麻疹成年患者维生素D水平降低
J Allergy Clin Immunol. 2010 Aug;126(2):413; author reply 413-4. doi: 10.1016/j.jaci.2010.04.040.
3
Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin.前沿：维生素D介导的针对结核分枝杆菌的人类抗菌活性依赖于cathelicidin的诱导。
J Immunol. 2007 Aug 15;179(4):2060-3. doi: 10.4049/jimmunol.179.4.2060.
4
VDR and MEK-ERK dependent induction of the antimicrobial peptide cathelicidin in keratinocytes by lithocholic acid.石胆酸通过VDR和MEK-ERK依赖性诱导角质形成细胞中的抗菌肽cathelicidin 。
Mol Immunol. 2009 Oct;46(16):3183-7. doi: 10.1016/j.molimm.2009.08.010. Epub 2009 Sep 5.
5
Antimicrobial peptides in health and disease.健康与疾病中的抗菌肽。
N Engl J Med. 2002 Oct 10;347(15):1199-200. doi: 10.1056/NEJMe020106.
6
The central role of Bcl-3 in atopic dermatitis.
J Invest Dermatol. 2009 Sep;129(9):2088-90. doi: 10.1038/jid.2009.178.
7
Expression of antimicrobial peptides in atopic dermatitis and possible immunoregulatory functions.在特应性皮炎中抗菌肽的表达及其可能的免疫调节功能。
Curr Opin Allergy Clin Immunol. 2013 Oct;13(5):531-6. doi: 10.1097/ACI.0b013e328364ddfd.
8
Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1.快速有效补充维生素 D 可能通过改变血清 INOS1、IL1B、IFNg、Cathelicidin-LL37 和 ICAM1 改善 COVID-19（SARS-CoV-2）患者的临床结局。
Nutrients. 2021 Nov 12;13(11):4047. doi: 10.3390/nu13114047.
9
Narrowband ultraviolet B treatment improves vitamin D balance and alters antimicrobial peptide expression in skin lesions of psoriasis and atopic dermatitis.窄谱中波紫外线治疗可改善银屑病和特应性皮炎皮损中的维生素 D 平衡，并改变抗菌肽的表达。
Br J Dermatol. 2010 Aug;163(2):321-8. doi: 10.1111/j.1365-2133.2010.09767.x. Epub 2010 Mar 17.
10
Effect of weekly vitamin D supplementation on the severity of atopic dermatitis and type 2 immunity biomarkers in children: A randomized controlled trial.每周补充维生素D对儿童特应性皮炎严重程度及2型免疫生物标志物的影响：一项随机对照试验。
J Eur Acad Dermatol Venereol. 2024 Sep;38(9):1760-1768. doi: 10.1111/jdv.19959. Epub 2024 Mar 14.

引用本文的文献

1
Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation.Cathelicidins：皮肤治疗与临床转化中的机遇与挑战
Antibiotics (Basel). 2024 Dec 24;14(1):1. doi: 10.3390/antibiotics14010001.
2
Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review.补充抗氧化剂在特应性皮炎治疗中的作用：一项批判性叙述性综述。
Front Nutr. 2024 Jun 12;11:1393673. doi: 10.3389/fnut.2024.1393673. eCollection 2024.
3
A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study).一项维生素 D 缺乏危重症患儿（VITdAL-PICU 研究）中胆钙化醇的 II 期剂量评估、可行性、随机对照试验。
BMC Pediatr. 2023 Aug 14;23(1):397. doi: 10.1186/s12887-023-04205-9.
4
Calcitriol, an Active Form of Vitamin D3, Mitigates Skin Barrier Dysfunction in Atopic Dermatitis NC/Nga Mice.活性维生素 D3 钙三醇可减轻特应性皮炎 NC/Nga 小鼠的皮肤屏障功能障碍。
Int J Mol Sci. 2023 May 27;24(11):9347. doi: 10.3390/ijms24119347.
5
Vitamin D and narrowband ultraviolet B phototherapy for chronic kidney disease-associated pruritus.维生素D与窄谱中波紫外线光疗用于治疗慢性肾脏病相关性瘙痒
Kidney Res Clin Pract. 2024 Mar;43(2):177-185. doi: 10.23876/j.krcp.22.153. Epub 2023 Mar 22.
6
Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis.口服维生素D可调节特应性皮炎患儿维生素D受体和杀菌肽的表皮表达。
Arch Dermatol Res. 2023 May;315(4):761-770. doi: 10.1007/s00403-022-02416-1. Epub 2022 Oct 22.
7
An Update on Narrowband Ultraviolet B Therapy for the Treatment of Skin Diseases.窄谱中波紫外线治疗皮肤病的最新进展
Cureus. 2021 Nov 1;13(11):e19182. doi: 10.7759/cureus.19182. eCollection 2021 Nov.
8
The immunopathogenesis and immunotherapy of cutaneous T cell lymphoma: Pathways and targets for immune restoration and tumor eradication.皮肤T细胞淋巴瘤的免疫发病机制与免疫治疗：免疫恢复和肿瘤根除的途径与靶点
J Am Acad Dermatol. 2021 Mar;84(3):587-595. doi: 10.1016/j.jaad.2020.12.027. Epub 2020 Dec 22.
9
Psoriasis and Antimicrobial Peptides.银屑病与抗菌肽。
Int J Mol Sci. 2020 Sep 16;21(18):6791. doi: 10.3390/ijms21186791.
10
Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing.血清 25-羟维生素 D 水平不足与支气管哮喘或哮喘样反复喘息患儿近期疾病加重史相关。
Int J Environ Res Public Health. 2020 Sep 9;17(18):6545. doi: 10.3390/ijerph17186545.

本文引用的文献

1
Antimicrobial peptides and the skin immune defense system.抗菌肽与皮肤免疫防御系统。
J Allergy Clin Immunol. 2008 Aug;122(2):261-6. doi: 10.1016/j.jaci.2008.03.027. Epub 2008 Apr 25.
2
Vitamin D deficiency.维生素D缺乏症
N Engl J Med. 2007 Jul 19;357(3):266-81. doi: 10.1056/NEJMra070553.
3
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.损伤通过维生素D依赖机制增强TLR2功能和抗菌肽表达。
J Clin Invest. 2007 Mar;117(3):803-11. doi: 10.1172/JCI30142. Epub 2007 Feb 8.
4
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.Toll样受体触发维生素D介导的人类抗菌反应。
Science. 2006 Mar 24;311(5768):1770-3. doi: 10.1126/science.1123933. Epub 2006 Feb 23.
5
10. Atopic dermatitis.10. 特应性皮炎。
J Allergy Clin Immunol. 2006 Feb;117(2 Suppl Mini-Primer):S475-80. doi: 10.1016/j.jaci.2005.10.018.
6
Endogenous antimicrobial peptides and skin infections in atopic dermatitis.特应性皮炎中的内源性抗菌肽与皮肤感染
N Engl J Med. 2002 Oct 10;347(15):1151-60. doi: 10.1056/NEJMoa021481.
7
Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level.摄入超过最低观察到有害作用水平的维生素D3的疗效和安全性。
Am J Clin Nutr. 2001 Feb;73(2):288-94. doi: 10.1093/ajcn/73.2.288.

Administration of oral vitamin D induces cathelicidin production in atopic individuals.

作者信息

Hata Tissa R, Kotol Paul, Jackson Michelle, Nguyen Meggie, Paik Aimee, Udall Don, Kanada Kimi, Yamasaki Kenshi, Alexandrescu Doru, Gallo Richard L

机构信息

Division of Dermatology, University of California San Diego, La Jolla, Calif.

Division of Dermatology, University of California San Diego, La Jolla, Calif.

出版信息

J Allergy Clin Immunol. 2008 Oct;122(4):829-831. doi: 10.1016/j.jaci.2008.08.020.

DOI:10.1016/j.jaci.2008.08.020
PMID:19014773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2659525/
Abstract
摘要