Myers Elisha, Kheradmand Shiva, Miller Richard
Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
Dermatology, Hospital Corporation of America/University of South Florida Morsani College of Medicine: Largo Medical Center, Largo, USA.
Cureus. 2021 Nov 1;13(11):e19182. doi: 10.7759/cureus.19182. eCollection 2021 Nov.
The objective of this review is to provide an update on narrowband ultraviolet B (NB-UVB) as a treatment for various skin conditions. NB-UVB works by suppressing the cutaneous cell-mediated immune response and has been shown to be an efficacious and clinically tolerable treatment for a range of inflammatory dermatoses. A literature search was conducted by advanced searches of PubMed for NB-UVB treatment of dermatologic skin diseases with a focus on reports from 2010 to 2021, including both office-based and home-based phototherapy (HBPT). Data were prioritized based on studies with a high level of evidence using the Oxford Evidence-Based Medicine guidance. We found that NB-UVB continues to serve as an effective form of therapy for several cutaneous conditions, including vitiligo, psoriasis, atopic dermatitis, mycosis fungoides, and other inflammatory dermatoses. The recent introduction of Janus kinase inhibitors in combination with NB-UVB suggests future promise in the treatment of vitiligo. Despite its rise in popularity, a decline was seen in office-based NB-UVB treatment during the coronavirus disease 2019 pandemic. Options are available to deliver NB-UVB at home with comparable efficacy to office-based treatments. In conclusion, for a select group of patients and conditions, NB-UVB continues to serve as an effective treatment modality with minimal side effects, with HBPT serving as an option to improve patient compliance.
本综述的目的是提供窄谱中波紫外线（NB-UVB）治疗各种皮肤疾病的最新情况。NB-UVB通过抑制皮肤细胞介导的免疫反应发挥作用，并且已被证明是治疗一系列炎症性皮肤病的有效且临床耐受性良好的疗法。通过在PubMed上进行高级搜索，对NB-UVB治疗皮肤病进行了文献检索，重点关注2010年至2021年的报告，包括门诊光疗和家庭光疗（HBPT）。根据牛津循证医学指南，基于具有高证据水平的研究对数据进行了优先排序。我们发现，NB-UVB仍然是治疗多种皮肤疾病的有效疗法，包括白癜风、银屑病、特应性皮炎、蕈样肉芽肿和其他炎症性皮肤病。最近引入的Janus激酶抑制剂与NB-UVB联合使用，显示出在白癜风治疗方面的未来前景。尽管NB-UVB越来越受欢迎，但在2019冠状病毒病大流行期间，门诊NB-UVB治疗有所下降。现在有在家中进行NB-UVB治疗的选择，其疗效与门诊治疗相当。总之，对于特定的一组患者和疾病，NB-UVB仍然是一种副作用最小的有效治疗方式，家庭光疗是提高患者依从性的一种选择。
