Awad J A, Deslauriers J, Major D, Guojin L, Martin L
Department of Surgery, Faculty of Medicine, Laval University, Ste-Foy, Québec, Canada.
Ann Thorac Surg. 1991 Apr;51(4):534-40. doi: 10.1016/0003-4975(91)90304-9.
A method of extracorporeal carbon dioxide extraction from the blood using an efficient microporous membrane oxygenator or membrane gas exchanger was evaluated during pumpless arteriovenous perfusions with a view to its application for partial respiratory support. The first study carried out in dogs revealed some increase in cardiac output, cardiac index, and cardiac work, although this increase was less than that normally expected from the added extracorporeal blood flow. In sheep during 3 to 7 days of continuous bypass, there was practically no hemolysis and relatively stable hemoglobin and hematocrit levels, and the platelet counts remained within safe levels. The maximum extracorporeal blood flow tended to decrease from a mean of 1.55 L/min on day 1 to 1.34 L/min on day 3 to 1.28 L/min on day 7. Carbon dioxide extraction remained efficient throughout the perfusion, but there was a minimal decrease from the first day (10.92 mmol/L) to the third day (8.46 mmol/L) at the higher blood carbon dioxide concentrations; it remained stable thereafter at 9.0 mmol/L.
为了将其应用于部分呼吸支持，在无泵动静脉灌注期间评估了一种使用高效微孔膜氧合器或膜式气体交换器从血液中体外提取二氧化碳的方法。在狗身上进行的第一项研究显示心输出量、心脏指数和心脏做功有所增加，尽管这种增加低于通常因体外血流量增加而预期的增加量。在绵羊连续旁路循环3至7天期间，几乎没有溶血现象，血红蛋白和血细胞比容水平相对稳定，血小板计数保持在安全水平内。最大体外血流量趋于下降，从第1天的平均1.55升/分钟降至第3天的1.34升/分钟，再降至第7天的1.28升/分钟。在整个灌注过程中，二氧化碳提取仍然有效，但在较高的血液二氧化碳浓度下，从第一天（10.92毫摩尔/升）到第三天（8.46毫摩尔/升）有轻微下降；此后保持在9.0毫摩尔/升稳定。
