Ukropec Jozef, Ukropcova Barbara, Kurdiova Timea, Gasperikova Daniela, Klimes Iwar
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Arch Physiol Biochem. 2008 Dec;114(5):357-68. doi: 10.1080/13813450802535812.
Obesity, accumulation of adipose tissue, develops when energy intake exceeds energy expenditure. Adipose tissue is essential for buffering the differences between energy intake and expenditure by accumulating lipids while skeletal muscle is the energy burning machine. Here we adopted the concept that (i) adipose tissue ability to regulate the storage capacity for lipids as well as (ii) dynamic regulation of muscle and adipose tissue secretory and metabolic activity is important for maintaining the metabolic health. This might be at least in part related to tissue plasticity, a phenomenon enabling dynamic modulation of the tissue phenotype in different physiological and pathophysiological situations. Recent advances in our understanding of the complex endocrine function of adipose tissue in regulating lipid metabolism, adipogenesis, angiogenesis, extracellular matrix remodelling, inflammation and oxidative stress prompted us to review the role of tissue plasticity--dynamic changes in adipose tissue and skeletal muscle metabolic and endocrine phenotype--in determining the difference between metabolic health and disease.
肥胖，即脂肪组织的堆积，是在能量摄入超过能量消耗时发生的。脂肪组织对于通过积累脂质来缓冲能量摄入与消耗之间的差异至关重要，而骨骼肌则是能量燃烧的机器。在这里，我们采用了这样的概念：（i）脂肪组织调节脂质储存能力的能力以及（ii）肌肉和脂肪组织分泌及代谢活性的动态调节对于维持代谢健康很重要。这可能至少部分与组织可塑性有关，组织可塑性是一种能够在不同生理和病理生理情况下动态调节组织表型的现象。我们对脂肪组织在调节脂质代谢、脂肪生成、血管生成、细胞外基质重塑、炎症和氧化应激方面复杂内分泌功能的理解取得了最新进展，这促使我们回顾组织可塑性——脂肪组织和骨骼肌代谢及内分泌表型的动态变化——在决定代谢健康与疾病差异方面的作用。
