Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain; Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain; Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
Curr Opin Pharmacol. 2020 Jun;52:1-8. doi: 10.1016/j.coph.2020.04.003. Epub 2020 May 5.
White (WAT) and brown (BAT) adipose tissue communicate with skeletal muscle and heart through the secretion of adipokines (adiponectin, leptin, omentin, osteopontin or cardiotrophin-1) and batokines (BMP8b, FGF-21, endothelin-1 or IL-6), respectively. Furthermore, several bioactive lipids termed lipokines [palmitoleate (C16:1n7) or 12,13-diHOME] and microRNAs capsuled in exosomes (miR-27a, miR122, miR-130b, miR-155, miR-200a or miR-320d) secreted from white and brown adipocytes also influence the skeletal and cardiac muscle function. The review focuses on the depot-related differences in adipose tissue-derived signals (adipokines, batokines, lipokines and exosomal miRNAs) and their impact on skeletal muscle under physiological conditions as well as in obesity. The relevance of regular physical activity and exercise on fat depot-specific adaptations to improve metabolic health will also be addressed.
白色（WAT）和棕色（BAT）脂肪组织通过分泌脂肪因子（脂联素、瘦素、网膜素、骨桥蛋白或心营养素-1）和 batokines（BMP8b、FGF-21、内皮素-1 或 IL-6）分别与骨骼肌和心脏进行通讯。此外，几种生物活性脂质被称为脂类（棕榈油酸（C16:1n7）或 12,13-二 HOMe）和外泌体中的 microRNAs（miR-27a、miR122、miR-130b、miR-155、miR-200a 或 miR-320d），这些脂质和 microRNAs 由白色和棕色脂肪细胞分泌，也会影响骨骼肌和心肌的功能。本综述重点介绍了脂肪组织来源的信号（脂肪因子、batokines、脂类和外泌体 microRNAs）在生理条件下以及肥胖症中与骨骼肌的 depot 相关差异及其对骨骼肌的影响。还将讨论定期体育活动和运动对改善代谢健康的脂肪 depot 特异性适应性的相关性。
