degli Uberti E C, Trasforini G, Margutti A, Ambrosio M R, Rossi R, Pansini R
Institute of Clinica Medica, University of Ferrara, Italy.
Neuroendocrinology. 1991 Feb;53(2):204-8. doi: 10.1159/000125719.
In this study we investigated the effect of intravenous infusion of angiotensin II (AII) on plasma luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in fertile healthy women examined both in the middle follicular phase (MFP) and in the middle luteal phase (MLP). As expected, AII induced a significant increase in blood pressure and plasma aldosterone concentration. In MFP, plasma FSH and LH levels did not show any significant change after AII infusion, if compared to both saline and preinfusion basal values. In MLP, AII significantly increased plasma LH (p less than 0.02 vs. baseline values and p less than 0.01 vs. placebo values), but not plasma FSH. The area under the curve during AII infusion resulted significantly higher than during placebo infusion (p less than 0.001). Therefore, these data demonstrate that peripherally injected AII at pressive dose produces an increase in plasma LH levels in normal women on luteal phase when the circulating concentrations of both estradiol and progesterone are high. The study suggests that AII may have a stimulatory role in the regulation of LH secretion, but this role is closely related to the gonadal steroid plasma levels.
在本研究中，我们调查了静脉输注血管紧张素II（AII）对处于卵泡中期（MFP）和黄体中期（MLP）的健康育龄妇女血浆促黄体生成素（LH）和促卵泡生成素（FSH）水平的影响。正如预期的那样，AII导致血压和血浆醛固酮浓度显著升高。在MFP中，与生理盐水和输注前基础值相比，输注AII后血浆FSH和LH水平未显示任何显著变化。在MLP中，AII显著升高了血浆LH（与基线值相比p<0.02，与安慰剂值相比p<0.01），但未升高血浆FSH。AII输注期间的曲线下面积显著高于安慰剂输注期间（p<0.001）。因此，这些数据表明，在雌二醇和孕酮循环浓度较高的黄体期，以升压剂量外周注射AII会使正常女性的血浆LH水平升高。该研究表明，AII可能在LH分泌调节中具有刺激作用，但这种作用与性腺类固醇血浆水平密切相关。
