Tiesler E, Hepp M
Immun Infekt. 1976 Aug;4(4):190-5.
In the sera of approximately 600 patients of all age groups, who were on clinical suspicion of an A-streptococcal infection, AST, ADNase B, AHy and ANADase were determined. The ANADase alone detects 90% of the acute A-streptococcal infections, the AHy and the ADNase B 80% and the ASO 50%. In skin infections superinfected by A-streptococci, the AHy is positive in 85%, the ANADase in 80%, the ADNase B in 75% and the AST in 40% of the cases. The most frequent A-streptococcal infection, Angina tonsillaris, is determined in the best manner possible through the combination ADNase B + ANADase + AHy. According to the statistical evaluation, the ADNase B and the ANADase are the most reliable tests. The age group of the 4 to 15 year-olds reaches for ASO, ADNase B and AHy a percentage of highly increased titers twice as high in comparison with the adult group. In no case does one test determine 100% of the collective; therefore, a combination of several antibody reactions is desirable for the diagnosis. Increased titers should be checked every four weeks, also normal titers with patients, who continue on the clinical suspicion of having an A-streptococcal infection, because their blood sample may have been taken before the immune reaction occurred.
在大约600名各年龄组、临床怀疑有A组链球菌感染的患者血清中，检测了AST、ADNase B、AHy和ANADase。仅ANADase就能检测出90%的急性A组链球菌感染，AHy和ADNase B能检测出80%，ASO能检测出50%。在被A组链球菌超级感染的皮肤感染中，AHy在85%的病例中呈阳性，ANADase在80%的病例中呈阳性，ADNase B在75%的病例中呈阳性，AST在40%的病例中呈阳性。最常见的A组链球菌感染——扁桃体炎，通过ADNase B + ANADase + AHy的组合能以最佳方式检测出来。根据统计评估，ADNase B和ANADase是最可靠的检测方法。4至15岁年龄组的ASO、ADNase B和AHy高滴度升高的百分比是成人组的两倍。没有一种检测能在所有病例中达到100%的检测率；因此，诊断时需要几种抗体反应的组合。滴度升高的情况应每四周检查一次，对于临床仍怀疑有A组链球菌感染的患者，即使滴度正常也应检查，因为他们的血样可能是在免疫反应发生之前采集的。
