生理响应性水凝胶的分子结构控制扩散行为。
Molecular structure of physiologically-responsive hydrogels controls diffusive behavior.
作者信息
Carr Daniel A, Peppas Nicholas A
机构信息
Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA.
出版信息
Macromol Biosci. 2009 May 13;9(5):497-505. doi: 10.1002/mabi.200800235.
Abstract
Polymeric networks and the ensuing hydrogels of MAA and NVP were successfully synthesized using a UV-initiated free radical polymerization and characterized to assess their applicability as carriers for directed drug delivery. FT-IR spectroscopy revealed shifts in peak absorbances that indicated the presence of hydrogen bonding complexes between functional groups, while SEM imaging showed that the different comonomers affect the surface morphology of the microparticles. Dynamic pH swelling studies demonstrated the pH responsiveness of the carriers in gastric and intestinal conditions and revealed that systems containing higher concentrations of MAA experienced the highest degree of hydrogen bonding complexation in gastric conditions. The presence of NVP in the systems enhanced swelling. Equilibrium swelling studies revealed that the mesh size was sufficiently large to allow drug diffusion across the networks.
摘要
采用紫外光引发自由基聚合法成功合成了甲基丙烯酸（MAA）和N-乙烯基吡咯烷酮（NVP）的聚合物网络及其形成的水凝胶，并对其进行了表征，以评估它们作为定向药物递送载体的适用性。傅里叶变换红外光谱（FT-IR）显示峰吸光度发生了位移，这表明官能团之间存在氢键复合物，而扫描电子显微镜（SEM）成像表明不同的共聚单体影响微粒的表面形态。动态pH溶胀研究证明了载体在胃和肠道条件下的pH响应性，并表明含有较高浓度MAA的体系在胃条件下经历了最高程度的氢键络合。体系中NVP的存在增强了溶胀。平衡溶胀研究表明，网孔尺寸足够大，能够使药物扩散穿过网络。
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