National Institute for Lasers Plasma and Radiation Physics, 409 Atomiștilor, 077125 Măgurele, Romania.
Faculty of Physics, University of Bucharest, 405 Atomiștilor, 077125 Măgurele, Romania.
Int J Mol Sci. 2020 Dec 3;21(23):9236. doi: 10.3390/ijms21239236.
We report on the successful preparation of wet dressings hydrogels based on Chitosan-Poly(N-Vinyl-Pyrrolidone)-Poly(ethylene glycol)-Poly(acrylic acid) and Poly(ethylene oxide) by e-beam cross-linking in weakly acidic media, to be used for rapid healing and pain release of infected skin wounds. The structure and compositions of hydrogels investigated according to sol-gel and swelling studies, network parameters, as well as FTIR and XPS analyses showed the efficient interaction of the hydrogel components upon irradiation, maintaining the bonding environment while the cross-linking degree increasing with the irradiation dose and the formation of a structure with the mesh size in the range 11-67 nm. Hydrogels with gel fraction above 85% and the best swelling properties in different pH solutions were obtained for hydrogels produced with 15 kGy. The hydrogels are stable in the simulated physiological condition of an infected wound and show appropriate moisture retention capability and the water vapor transmission rate up to 272.67 g m day, to ensure fast healing. The hydrogels proved to have a significant loading capacity of ibuprofen (IBU), being able to incorporate a therapeutic dose for the treatment of severe pains. Simultaneously, IBU was released up to 25% in the first 2h, having a release maximum after 8 h.
我们报告了成功制备基于壳聚糖-聚（N-乙烯基吡咯烷酮）-聚（乙二醇）-聚（丙烯酸）和聚（氧化乙烯）的湿敷料水凝胶，该水凝胶通过在弱酸性介质中的电子束交联制备，用于快速治愈和缓解感染皮肤伤口的疼痛。根据溶胶-凝胶和溶胀研究、网络参数以及 FTIR 和 XPS 分析研究了水凝胶的结构和组成，结果表明水凝胶成分在辐照下有效相互作用，在交联度增加的同时保持键合环境，并且形成了一种具有 11-67nm 范围内的网格尺寸的结构。对于辐照剂量为 15kGy 时制备的水凝胶，获得了凝胶分数高于 85%且在不同 pH 值溶液中具有最佳溶胀性能的水凝胶。水凝胶在感染性伤口的模拟生理条件下稳定，并具有适当的保水能力和水蒸气透过率高达 272.67gm-2day-1，以确保快速愈合。水凝胶被证明具有显著的布洛芬（IBU）负载能力，能够负载治疗严重疼痛的治疗剂量。同时，IBU 在最初的 2 小时内释放了高达 25%，8 小时后达到释放最大值。
