新型碳青霉烯类药物LJC10,627对脱氢肽酶I稳定的体外及体内活性
In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I.
作者信息
Petersen P J, Jacobus N V, Weiss W J, Testa R T
机构信息
Medical Research Division, American Cyanamid Co., Pearl River, New York 10965.
出版信息
Antimicrob Agents Chemother. 1991 Jan;35(1):203-7. doi: 10.1128/AAC.35.1.203.
Abstract
The activity of LJC10,627 was compared with the activities of imipenem and other antibiotics. LJC10,627 was more active against most members of the family Enterobacteriaceae, Pseudomonas spp., and Acinetobacter spp. but slightly less active than imipenem against staphylococci and streptococci. LJC10,627 showed stability to mouse dehydropeptidase I and was more effective in vivo than imipenem plus cilastatin against gram-negative bacterial infections and as effective against staphylococcal infections.
摘要
将LJC10,627的活性与亚胺培南及其他抗生素的活性进行了比较。LJC10,627对大多数肠杆菌科细菌、假单胞菌属和不动杆菌属成员的活性更强，但对葡萄球菌和链球菌的活性略低于亚胺培南。LJC10,627对小鼠脱氢肽酶I具有稳定性，并且在体内抗革兰氏阴性菌感染方面比亚胺培南加西司他丁更有效，在抗葡萄球菌感染方面同样有效。
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