新型碳青霉烯类药物LJC10,627对脱氢肽酶I稳定的体外及体内活性
In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I.
作者信息
Petersen P J, Jacobus N V, Weiss W J, Testa R T
机构信息
Medical Research Division, American Cyanamid Co., Pearl River, New York 10965.
出版信息
Antimicrob Agents Chemother. 1991 Jan;35(1):203-7. doi: 10.1128/AAC.35.1.203.
Abstract
The activity of LJC10,627 was compared with the activities of imipenem and other antibiotics. LJC10,627 was more active against most members of the family Enterobacteriaceae, Pseudomonas spp., and Acinetobacter spp. but slightly less active than imipenem against staphylococci and streptococci. LJC10,627 showed stability to mouse dehydropeptidase I and was more effective in vivo than imipenem plus cilastatin against gram-negative bacterial infections and as effective against staphylococcal infections.
摘要
将LJC10,627的活性与亚胺培南及其他抗生素的活性进行了比较。LJC10,627对大多数肠杆菌科细菌、假单胞菌属和不动杆菌属成员的活性更强，但对葡萄球菌和链球菌的活性略低于亚胺培南。LJC10,627对小鼠脱氢肽酶I具有稳定性，并且在体内抗革兰氏阴性菌感染方面比亚胺培南加西司他丁更有效，在抗葡萄球菌感染方面同样有效。
相似文献
1
In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I.新型碳青霉烯类药物LJC10,627对脱氢肽酶I稳定的体外及体内活性
Antimicrob Agents Chemother. 1991 Jan;35(1):203-7. doi: 10.1128/AAC.35.1.203.
2
In vitro activity of LJC10,627, a new carbapenem antibiotic with high stability to dehydropeptidase I.新型碳青霉烯类抗生素LJC10,627对脱氢肽酶I具有高稳定性的体外活性。
Antimicrob Agents Chemother. 1990 Jun;34(6):994-1000. doi: 10.1128/AAC.34.6.994.
3
In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase I.对脱氢肽酶I稳定的碳青霉烯类抗生素SM-7338的体外抗菌活性
Antimicrob Agents Chemother. 1989 Feb;33(2):215-22. doi: 10.1128/AAC.33.2.215.
4
In-vitro activities of various antibiotics, alone and in combination with amikacin against Pseudomonas aeruginosa.多种抗生素单独及与阿米卡星联合使用对铜绿假单胞菌的体外活性。
J Antimicrob Chemother. 1995 Oct;36(4):707-11. doi: 10.1093/jac/36.4.707.
5
In vitro antibacterial activity and beta-lactamase stability of the new carbapenem LJC10,627.新型碳青霉烯类药物LJC10,627的体外抗菌活性及β-内酰胺酶稳定性
Eur J Clin Microbiol Infect Dis. 1990 Aug;9(8):625-9. doi: 10.1007/BF01967222.
6
In-vitro activity of meropenem against clinical isolates in a multicentre study in Italy.美罗培南在意大利一项多中心研究中对临床分离株的体外活性。
J Antimicrob Chemother. 1989 Sep;24 Suppl A:57-72. doi: 10.1093/jac/24.suppl_a.57.
7
Assessing the pharmacodynamic profile of intravenous antibiotics against prevalent Gram-negative organisms collected in Colombia.评估静脉用抗生素对哥伦比亚流行的革兰氏阴性菌的药效学特征。
Braz J Infect Dis. 2011 Sep-Oct;15(5):413-9. doi: 10.1016/s1413-8670(11)70221-5.
8
In vitro activity of fosfomycin combined with ceftazidime, imipenem, amikacin, and ciprofloxacin against Pseudomonas aeruginosa.磷霉素与头孢他啶、亚胺培南、阿米卡星及环丙沙星联合对铜绿假单胞菌的体外活性
Eur J Clin Microbiol Infect Dis. 1997 Feb;16(2):159-62. doi: 10.1007/BF01709477.
9
In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity.新型碳青霉烯类抗生素BO-2727的体外活性，其具有强大的抗假单胞菌活性。
Antimicrob Agents Chemother. 1993 Dec;37(12):2756-9. doi: 10.1128/AAC.37.12.2756.
10
An evaluation of the in vitro activity of piperacillin/tazobactam.哌拉西林/他唑巴坦的体外活性评估。
Pathology. 1996 May;28(2):167-72. doi: 10.1080/00313029600169813.
引用本文的文献
1
Biapenem versus meropenem in the treatment of bacterial infections: a multicenter, randomized, controlled clinical trial.比阿培南与美罗培南治疗细菌感染的多中心、随机、对照临床试验
Indian J Med Res. 2013 Dec;138(6):995-1002.
2
Comparative effects of carbapenems on bacterial load and host immune response in a Klebsiella pneumoniae murine pneumonia model.碳青霉烯类抗生素对肺炎克雷伯菌小鼠肺炎模型中细菌负荷和宿主免疫反应的比较影响。
Antimicrob Agents Chemother. 2011 Feb;55(2):836-44. doi: 10.1128/AAC.00670-10. Epub 2010 Dec 6.
3
In vitro antimicrobial activity of doripenem, a new carbapenem.新型碳青霉烯类药物多利培南的体外抗菌活性
Antimicrob Agents Chemother. 2004 Apr;48(4):1384-96. doi: 10.1128/AAC.48.4.1384-1396.2004.
4
Emerging strategies in infectious diseases: new carbapenem and trinem antibacterial agents.传染病的新兴策略：新型碳青霉烯类和三联抗菌剂
Drugs. 2001;61(5):553-64. doi: 10.2165/00003495-200161050-00001.
5
In vitro activities of aminomethyl-substituted analogs of novel tetrahydrofuranyl carbapenems.新型四氢呋喃基碳青霉烯类氨基甲基取代类似物的体外活性
Antimicrob Agents Chemother. 1999 Mar;43(3):454-9. doi: 10.1128/AAC.43.3.454.
6
Antimicrobial activity of the new carbapenem biapenem compared to imipenem, meropenem and other broad-spectrum beta-lactam drugs.新型碳青霉烯类药物比阿培南与亚胺培南、美罗培南及其他广谱β-内酰胺类药物的抗菌活性比较。
Eur J Clin Microbiol Infect Dis. 1993 May;12(5):384-91. doi: 10.1007/BF01964439.
7
In vitro activity of biapenem against clinical isolates of gram-positive and gram-negative bacteria.比阿培南对革兰氏阳性和革兰氏阴性菌临床分离株的体外活性。
Antimicrob Agents Chemother. 1993 Sep;37(9):2009-16. doi: 10.1128/AAC.37.9.2009.
8
In vitro activity of biapenem against beta-lactamase producing Enterobacteriaceae.比阿培南对产β-内酰胺酶肠杆菌科细菌的体外活性
Eur J Clin Microbiol Infect Dis. 1994 Oct;13(10):820-2. doi: 10.1007/BF02111342.
9
In vitro activity and beta-lactamase stability of LJC 10,627.LJC 10,627的体外活性及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1992 Jul;36(7):1418-23. doi: 10.1128/AAC.36.7.1418.
10
Biochemical characterization of the metallo-beta-lactamase CcrA from Bacteroides fragilis TAL3636.脆弱拟杆菌TAL3636中金属β-内酰胺酶CcrA的生化特性
Antimicrob Agents Chemother. 1992 May;36(5):1155-7. doi: 10.1128/AAC.36.5.1155.
本文引用的文献
1
Thienamycin: development of imipenen-cilastatin.硫霉素：亚胺培南-西司他丁的研发
J Antimicrob Chemother. 1983 Dec;12 Suppl D:1-35. doi: 10.1093/jac/12.suppl_d.1.
2
The purification and properties of a particulate renal dipeptidase.一种颗粒性肾二肽酶的纯化及特性
Biochim Biophys Acta. 1966 May 5;118(2):371-86. doi: 10.1016/s0926-6593(66)80046-2.
3
Efficacy and safety of imipenem/cilastatin: a review of worldwide clinical experience.
Rev Infect Dis. 1985 Jul-Aug;7 Suppl 3:S528-36. doi: 10.1093/clinids/7.supplement_3.s528.
4
In vitro and pharmacokinetic properties of the carbapenems.碳青霉烯类药物的体外及药代动力学特性。
Antimicrob Agents Chemother. 1986 Sep;30(3):343-9. doi: 10.1128/AAC.30.3.343.
5
Imipenem: a new carbapenem antibiotic.亚胺培南：一种新型碳青霉烯类抗生素。
Med Clin North Am. 1988 May;72(3):567-79. doi: 10.1016/s0025-7125(16)30759-3.
Zotero 插件