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女性美发师及其姐妹所生婴儿的出生体重与胎儿生长情况。

Birth weight and fetal growth in infants born to female hairdressers and their sisters.

作者信息

Axmon A, Rylander L

机构信息

Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, University Hospital, Lund, Sweden.

出版信息

Occup Environ Med. 2009 Mar;66(3):198-204. doi: 10.1136/oem.2008.039784. Epub 2008 Nov 18.

Abstract

OBJECTIVES

To investigate birth weight and fetal growth in female hairdressers, while controlling for intergenerational effects and effects related to childhood exposures.

METHODS

A cohort of women who had attended vocational schools for hairdressers were compared to their sisters with respect to birth weight and fetal growth (measured as small for gestational age (SGA) or large for gestational age (LGA), respectively) in their infants. In total, 6223 infants born to 3137 hairdressers and 8388 infants born to 3952 hairdressers' sisters were studied.

RESULTS

Among the infants born to the hairdressers' sisters, the distribution of birth weights were wider than that among the infants born to the hairdressers. This was also reflected in that hairdresser cohort affiliation tended to be protective against both SGA (odds ratio 0.80; 95% confidence interval 0.49 to 1.31) and LGA (0.77; 0.54 to 1.09). For LGA, this effect was even more pronounced among women who had actually worked as hairdressers during at least one pregnancy (0.60; 0.39 to 0.92). The infants born to these women also had a significantly lower mean birth weight (3387 g vs 3419 g; p = 0.033).

CONCLUSIONS

The results from the present study suggest that infants born to hairdressers have a decreased risk of being LGA. This is most likely not caused by a shift in birth weight distribution or abnormal glucose metabolism.

摘要

目的

在控制代际效应和与儿童期暴露相关的效应的同时,调查女性美发师的出生体重和胎儿生长情况。

方法

将一组曾就读于美发师职业学校的女性与其姐妹在婴儿出生体重和胎儿生长情况(分别以小于胎龄儿(SGA)或大于胎龄儿(LGA)衡量)方面进行比较。总共研究了3137名美发师所生的6223名婴儿以及3952名美发师姐妹所生的8388名婴儿。

结果

在美发师姐妹所生的婴儿中,出生体重的分布比美发师所生婴儿的分布更广泛。这也体现在美发师队列关联倾向于对SGA(比值比0.80;95%置信区间0.49至1.31)和LGA(0.77;0.54至1.09)均具有保护作用。对于LGA,这种效应在至少一次怀孕期间实际从事美发师工作的女性中更为明显(0.60;0.39至0.92)。这些女性所生的婴儿平均出生体重也显著更低(3387克对3419克;p = 0.033)。

结论

本研究结果表明,美发师所生婴儿患LGA的风险降低。这很可能不是由出生体重分布的变化或异常糖代谢引起的。

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