Macnee William, Maclay John, McAllister David
ELEGI Colt Research Labs, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK.
Proc Am Thorac Soc. 2008 Dec 1;5(8):824-33. doi: 10.1513/pats.200807-071TH.
Cardiovascular disease represents a considerable burden in terms of both morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD). For 20 years, forced expiratory volume in 1 second (FEV(1)) has been an established predictor of cardiovascular mortality among smokers, never-smokers, and patients with COPD. We review evidence for increased cardiovascular risk in COPD. In addition, we assess the emerging evidence which suggests that hypoxia, systemic inflammation, and oxidative stress in patients with COPD may cause cardiovascular disease. We also discuss alternative hypotheses that the endothelium and connective tissues in the arteries and lungs of patients with COPD and cardiovascular disease have a shared susceptibility to these factors.
心血管疾病在慢性阻塞性肺疾病（COPD）患者的发病率和死亡率方面都构成了相当大的负担。20年来，1秒用力呼气容积（FEV₁）一直是吸烟者、从不吸烟者和COPD患者心血管死亡率的既定预测指标。我们回顾了COPD患者心血管风险增加的证据。此外，我们评估了新出现的证据，这些证据表明COPD患者的缺氧、全身炎症和氧化应激可能导致心血管疾病。我们还讨论了其他假说，即COPD和心血管疾病患者的动脉和肺部内皮及结缔组织对这些因素具有共同易感性。
