Nguyen Lam Tung, Uchida Tomohisa, Murakami Kazunari, Fujioka Toshio, Moriyama Masatsugu
Department of Gastroenterology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879-5593, Japan.
J Med Microbiol. 2008 Dec;57(Pt 12):1445-1453. doi: 10.1099/jmm.0.2008/003160-0.
Infection with cagPAI positive strains of Helicobacter pylori is recognized as being associated with an increased risk of gastric cancer. This article reviews the current knowledge on the structures and pathological functions of cagPAI and the CagA protein, focusing especially on the molecular mechanism through which CagA may be involved in gastric carcinogenesis. The possible link between the geographical distribution of cagPAI and cagA variations and gastric cancer diversity in Asia is also discussed.
幽门螺杆菌cagPAI阳性菌株感染被认为与胃癌风险增加有关。本文综述了目前关于cagPAI和CagA蛋白的结构及病理功能的知识，尤其关注CagA可能参与胃癌发生的分子机制。还讨论了亚洲地区cagPAI和cagA变异的地理分布与胃癌多样性之间的可能联系。
