Faber J, Vos P, Kegler D, van Norren K, Argilés J M, Laviano A, Garssen J, van Helvoort A
Danone Research - Centre for Specialised Nutrition (formerly known as Numico Research), Wageningen, The Netherlands.
Br J Cancer. 2008 Dec 16;99(12):2029-36. doi: 10.1038/sj.bjc.6604785. Epub 2008 Nov 18.
The majority of patients with advanced cancer are recognised by impaired immune competence influenced by several factors, including the type and stage of the tumour and the presence of cachexia. Recently, a specific nutritional combination containing fish oil, specific oligosaccharide mixture, high protein content and leucine has been developed aimed to support the immune system of cancer patients in order to reduce the frequency and severity of (infectious) complications. In a recently modified animal model cachexia is induced by inoculation of C26 tumour cells in mice. In a pre-cachectic state, no effect was observed on contact hypersensitivity, a validated in vivo method to measure Th1-mediated immune function, after adding the individual nutritional ingredients to the diet of tumour-bearing mice. However, the complete mixture resulted in significantly improved Th1 immunity. Moreover, in a cachectic state, the complete mixture reduced plasma levels of pro-inflammatory cytokines and beneficially affected ex vivo immune function. Accordingly, the combination of the nutritional ingredients is required to obtain a synergistic effect, leading to a reduced inflammatory state and improved immune competence. From this, it can be concluded that the specific nutritional combination has potential as immune-supporting nutritional intervention to reduce the risk of (infectious) complications in cancer patients.
大多数晚期癌症患者因受多种因素影响而免疫功能受损，这些因素包括肿瘤的类型和分期以及恶病质的存在。最近，一种含有鱼油、特定低聚糖混合物、高蛋白含量和亮氨酸的特定营养组合已被研发出来，旨在支持癌症患者的免疫系统，以降低（感染性）并发症的发生频率和严重程度。在最近改良的动物模型中，通过给小鼠接种C26肿瘤细胞来诱导恶病质。在恶病质前期状态下，将单独的营养成分添加到荷瘤小鼠的饮食中后，未观察到对接触性超敏反应（一种用于测量Th1介导的免疫功能的有效体内方法）有任何影响。然而，完整的混合物显著改善了Th1免疫。此外，在恶病质状态下，完整的混合物降低了促炎细胞因子的血浆水平，并对体外免疫功能产生了有益影响。因此，需要营养成分的组合来获得协同效应，从而减轻炎症状态并提高免疫能力。由此可以得出结论，这种特定的营养组合有潜力作为免疫支持性营养干预措施，以降低癌症患者发生（感染性）并发症的风险。
